COATINGS CONTAINING MULTIPLE DRUGS
A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.
1 . A pharmaceutical product comprising:
a. a core, and
b. a coating deposited on said core, said coating comprising at least one polymer layer in dry powder form, and
c. at least one pharmaceutical layer comprising a pharmaceutical agent having a morphology that is crystalline or semi-crystalline.
2 . The pharmaceutical product of claim 1 , wherein said at least one polymer comprises a bioabsorbable polymer.
3 . The pharmaceutical product of claim 1 , wherein said at least one polymer layer comprises a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been substantially modified.
4 . The pharmaceutical product of claim 1 , wherein said polymer of said at least one polymer layer is selected from PLA, PLGA, PGA, and Poly(dioxanone).
5 . The pharmaceutical product of claim 1 , wherein said coating comprises five or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical agent;
a second polymer layer;
a second pharmaceutical layer comprising a second pharmaceutical agent; and
a third polymer layer.
6 . The pharmaceutical product of claim 1 , wherein said coating comprises four or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical agent;
a second polymer layer; and
a second pharmaceutical layer comprising a second pharmaceutical agent.
7 . The pharmaceutical product of claim 1 , comprising four or more layers, as follows:
the first pharmaceutical layer comprising a first pharmaceutical agent;
a first polymer layer;
a second pharmaceutical layer comprising a second pharmaceutical agent; and
a second polymer layer.
8 . The pharmaceutical product of claim 1 , wherein said pharmaceutical layer and said at least one polymer layer comprise alternate layers of pharmaceutical agent, or pharmaceutical agent and polymer, and layers of polymer without pharmaceutical agents.
9 . A pharmaceutical product comprising:
a coating composition comprising at least one polymer layer,
a pharmaceutical layer comprising at least one pharmaceutical agent, and
wherein said at least one polymer layer comprises a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been substantially modified, and
said first pharmaceutical agent is crystalline or semi-crystalline.
10 . The pharmaceutical product of claim 9 , wherein said at least one polymer layer comprises a bioabsorbable polymer.
11 . The pharmaceutical product of claim 9 , wherein said polymer of said at least one polymer layer is selected from PLA, PLGA, PGA, and Poly(dioxanone).
12 . The pharmaceutical product of claim 9 , comprising five or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical agent;
a second polymer layer;
a second pharmaceutical layer comprising a second pharmaceutical agent; and
a third polymer layer.
13 . The pharmaceutical product of claim 9 , comprising four or more layers, as follows:
a first polymer layer;
a first pharmaceutical layer comprising said at least one pharmaceutical agent;
a second polymer layer; and
a second pharmaceutical layer comprising a second pharmaceutical agent.
14 . The pharmaceutical product of claim 9 , wherein said pharmaceutical layer and said at least one polymer layer comprise alternate layers of pharmaceutical agent, or pharmaceutical agent and polymer, and layers of polymer without pharmaceutical agent.