TETRACYCLINE COMPOUNDS HAVING TARGET THERAPEUTIC ACTIVITIES
Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.
1 - 132 . (canceled)
133 . A method for treating a disease with a tetracycline compound having a target therapeutic activity, comprising administering to a subject in need thereof an effective amount of a tetracycline compound having said target therapeutic activity, or a pharmaceutically acceptable salt thereof, such that said disease in said subject is treated;
wherein said disease is selected from the group consisting of an inflammatory disorder caused by radiation, a traumatic brain injury and a wound; and
wherein said tetracycline compound is the compound of the following structural formula:
134 . The method of claim 133 , wherein said disease is an inflammatory disorder caused by radiation.
135 . The method of claim 133 , wherein said disease is a traumatic brain injury.
136 . The method of claim 133 , wherein said disease is a wound.
137 . A method for treating a disease with a tetracycline compound having a target therapeutic activity, comprising administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a tetracycline compound having said target therapeutic activity, or a pharmaceutically acceptable salt thereof, such that said disease in said subject is treated;
wherein said disease is selected from the group consisting of an inflammatory disorder caused by radiation, a traumatic brain injury and a wound; and
wherein said tetracycline compound is the compound of the following structural formula:
138 . The method of claim 137 , wherein said disease is an inflammatory disorder caused by radiation.
139 . The method of claim 137 , wherein said disease is a traumatic brain injury.
140 . The method of claim 137 , wherein said disease is a wound.
141 . A method for treating disease, comprising administering to a subject in need thereof an effective amount of a tetracycline compound of the following structural formula:
or a pharmaceutically acceptable salt thereof, such that said disease in said subject is treated;
wherein said disease is selected from the group consisting of an inflammatory disorder caused by radiation, a traumatic brain injury and a wound.
142 . The method of claim 141 , wherein said disease is an inflammatory disorder caused by radiation.
143 . The method of claim 141 , wherein said disease is a traumatic brain injury.
144 . The method of claim 141 , wherein said disease is a wound.
145 . A method for treating a disease, comprising administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of a tetracycline compound of the following structural formula:
or a pharmaceutically acceptable salt thereof, such that said disease in said subject is treated;
wherein said disease is selected from the group consisting of an inflammatory disorder caused by radiation, a traumatic brain injury and a wound.
146 . The method of claim 145 , wherein said disease is an inflammatory disorder caused by radiation.
147 . The method of claim 145 , wherein said disease is a traumatic brain injury.
148 . The method of claim 145 , wherein said disease is a wound.