Solvent system for use with spot-on pesticide compositions
A solvent system, and spot-on pesticide composition comprising the solvent system and a combination of active pesticidal compounds for the treatment or prevention of insect, parasite, or tick infestations in animals, specifically mammals, including dogs and cats. The solvent system is capable of allowing high concentrations of the active pesticides, while maintaining shelf life and resistance to repeated cycles of freezing and thawing normally encountered during shipping, for example.
1. A spot-on pesticide composition for controlling pests on animals, the composition consisting of two or more active pesticidal compounds and a solvent system, wherein the solvent system consists of urea, N-methylpyrrolidone (NMP), and N-ethylpyrrolidone (NEP) and wherein the composition optionally comprises an insect growth regulator and an antioxidant.
2. The spot-on pesticide composition of claim 1 , wherein the composition consists of between about 50% to about 60% (w/w) of the two or more active pesticidal compounds and between about 40% to about 50% (w/w) of the solvent system.
3. The spot-on pesticide composition of claim 2 , wherein the solvent system consists of between about 0.5% and about 1.5% (w/w) urea, between about 40% and about 70% (w/w) NMP, and between about 30% and about 60% (w/w) NEP.
4. The solvent system of claim 3 , wherein the solvent system consists of between about 0.7% to about 1.2% (w/w) urea.
5. The solvent system of claim 3 , wherein the solvent system consists of between about 52% and about 57% (w/w) NEP, between about 52% and about 57% (w/w) NMP, and between about 0.3% and about 0.5% (w/w) urea.
6. The spot-on pesticide composition of claim 1 , wherein the two or more active pesticidal compounds comprises a neonicotinoid and a pyrethroid.
7. The spot-on pesticide composition of claim 6 , wherein the two or more active pesticidal compounds comprises between about 10% to about 30% (w/w) of a neonicotinoid and between about 70% to about 90% (w/w) of a pyrethroid.
8. The spot-on pesticide composition of claim 1 , wherein the two or more active pesticidal compounds comprises between about 10% to about 30% (w/w) of a neonicotinoid, between about 70% to about 90% (w/w) of a pyrethroid, and about 0% to about 5% (w/w) of an insect growth regulator.
9. The spot-on pesticide composition of claim 1 , wherein the two or more active pesticidal compounds comprises between about 1% to about 20% (w/w) of a neonicotinoid and between about 1% to about 70% (w/w) of a pyrethroid.
10. The spot-on pesticide composition of claim 9 , wherein the neonicotinoid is selected from the group consisting of imidacloprid, acetamiprid, nithiazine, thiamethoxam, dinotefuran, nitenpyram, thiacloprid, clothianadin, and combinations thereof.
11. The spot-on pesticide composition of claim 9 , wherein the neonicotinoid is imidacloprid.
12. The spot-on pesticide composition of claim 11 , wherein the two or more active pesticidal compounds comprises between about 5% to about 15% (w/w) imidacloprid.
13. The spot-on pesticide composition of claim 9 , wherein the pyrethroid is selected from the group consisting of permethrin, cypermethrin, cyphenothrin, etofenprox, fenvalerate, cyfluthrin, and combinations thereof.
14. The spot-on pesticide composition of claim 13 , wherein the pyrethroid is permethrin.
15. The spot-on pesticide composition of claim 14 , wherein the two or more active pesticidal compounds comprises between about 40% to about 50% (w/w) permethrin.
16. The spot-on pesticide composition of claim 9 , wherein the two or more active pesticidal compounds further comprises between about 0.01% and about 20% (w/w) of an insect growth regulator.
17. The spot-on pesticide composition of claim 1 , wherein the composition further consists of between about 0% and about 10% (w/w) of an antioxidant selected from the group consisting of tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, tocopherol succinate, ascorbyl tocopherol phosphate, dioleyl tocopherol methylsilanol, tocophersolan, tocopherol linoleate/oleate, p-aminobenzoic acid (PABA), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and combinations thereof.
18. The spot-on pesticide composition of claim 17 , wherein the antioxidant is BHT.
19. The spot-on pesticide composition of claim 16 , wherein the insect growth regulator is a juvenile hormone mimic, a chitin synthesis inhibitor, and combinations thereof.
20. The spot-on pesticide composition of claim 19 , wherein the insect growth regulator is selected from the group consisting of S-methoprene, pyriproxyfen, novaluron, and combinations thereof.
21. The spot-on pesticide composition of claim 20 , wherein the insect growth regulator is pyriproxyfen.
22. The spot-on pesticide composition of claim 1 , wherein the solvent system consists of between about 40% to about 70% (w/w) NEP, between about 30% to about 60% (w/w) NMP, and between about 0.1% and about 5% (w/w) urea.
23. The spot-on pesticide composition of claim 1 , wherein the composition consists of between about 7.5% and about 9.5% (w/w) imidacloprid, between about 42% and about 46% (w/w) permethrin, between about 0.4% to about 0.5% (w/w) pyriproxyfen, between about 0.05% and about 1.5% (w/w) BHT, and about 44% (w/w) of a solvent system consisting of between about 22% to about 26% (w/w of the overall composition) NEP, between about 18% to about 22% (w/w of the overall composition) NMP, and between about 0.3% and about 0.5% (w/w of the overall composition) urea.
24. A spot-on pesticide composition consisting of between about 1% and about 20% (w/w) of a neonicotinoid, between about 1% and about 70% (w/w) of a pyrethroid, between about 0.01% and about 20% (w/w) of an insect growth regulator, between about 0.01% and about 10% (w/w) of an antioxidant, and between about 10% and about 98% (w/w) of a solvent system consisting of urea, NMP, and NEP.
25. A solvent system for improved storage stability of spot-on pesticide compositions, wherein the solvent system consists of between about 0.5% and about 1.5% (w/w) urea, between about 40% and about 70% (w/w) NEP, and between about 30% and about 60% (w/w) NMP.
26. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition consisting of between about 1% and about 20% (w/w) of a neonicotinoid, between about 1% and about 70% (w/w) of a pyrethroid, optionally between about 0.01% and about 20% (w/w) of an insect growth regulator, optionally between about 0.01% and about 10% (w/w) of an antioxidant, and between about 10% and about 98% (w/w) of a solvent system consisting of urea, NMP, and NEP.
27. The method of claim 26 , wherein the spot-on composition consists of between about 7.5% and about 9.5% (w/w) imidacloprid, between about 42% and about 46% (w/w) permethrin, between about 0.4% to about 0.5% (w/w) pyriproxyfen, between about 0.05% and about 1.5% (w/w) BHT, and about 44% (w/w) of a solvent system, the solvent system consisting of between about 22% to about 26% (w/w of the overall composition) NEP, between about 18% to about 22% (w/w of the overall composition) NMP, and between about 0.3% and about 0.5% (w/w of the overall composition) urea.
28. The method of claim 26 , wherein the animal is a mammal.
29. The method of claim 28 , wherein the mammal comprises a dog or a cat.