Embedded liquid lubricants for tableting
The invention provides a nutritional supplement and/or pharmaceutical composition for tableting comprising an embedded lubrication matrix. The embedded lubrication matrix comprises an oily liquid finely dispersed in an oil insoluble material. A method of lubricating a nutritional supplement or pharmaceutical composition for tableting using a matrix with embedded lubrication is also provided.
1. A nutritional supplement tablet composition comprising 0.1% to 1.5% weight/weight of an embedded lubrication matrix, wherein the embedded lubrication matrix comprises Vitamin E oil finely dispersed in an oil insoluble material and interspersed in interstitial spaces of the oil insoluble material, wherein the oil-insoluble material does not assemble a layer over the surface of the Vitamin E oil, and wherein the nutritional supplement composition comprises less than 0.01% stearate by weight.
2. The nutritional supplement tablet composition of claim 1 , wherein the oil-insoluble material is selected from the group consisting of starch, dextrin, microcrystalline cellulose, ethylcellulose, gelatin, glucose, maltose, fructose, sorbitol, sucrose, mannitol, sorbitol, lactose, methylcellulose, hydroxypropylmethyl cellulose, maltodextrin, silicon dioxide, anhydrous dicalcium phosphate, and combinations thereof.
3. The nutritional supplement tablet composition of claim 1 , wherein the composition further comprises at least one mineral.
4. The nutritional supplement tablet composition of claim 1 , wherein the composition further comprises at least one vitamin.
5. The nutritional supplement composition of claim 1 , wherein the composition further comprises at least one nutritional agent.
6. The nutritional supplement tablet composition of claim 5 , wherein the at least one nutritional agent is selected from the group consisting of carotenoids, fiber, phytosterols, glucosides, polyphenols, B complex related compounds, omega-3 fatty acids, probiotics, glucosamine, amino acids, peptides, and combinations thereof.
7. The nutritional supplement tablet composition of claim 1 , further composing at least one vitamin and at least one mineral.
8. The nutritional supplement tablet composition of claim 1 , wherein the composition is a direct compression composition.
9. The nutritional supplement tablet composition of claim 1 , wherein the composition comprises a granulation.
10. A multivitamin and mineral composition comprising 0.1% to 1.5% weight/weight of an embedded lubrication matrix wherein the embedded lubrication matrix comprises Vitamin E oil finely dispersed in an oil insoluble material and interspersed in interstitial spaces of the oil insoluble material, wherein the oil-insoluble material does not assemble a layer over the surface of the Vitamin E oil, and wherein the nutritional supplement composition comprises less than 0.01% stearate by weight.
11. The multivitamin and mineral composition of claim 10 , wherein the oil-insoluble material is selected from the group consisting of starch, dextrin, microcrystalline cellulose, ethylcellulose, gelatin, glucose, maltose, fructose, sorbitol, sucrose, mannitol, sorbitol, lactose, methylcellulose, hydroxypropylmethyl cellulose, maltodextrin, silicon dioxide, anhydrous dicalcium phosphate, and combinations thereof.
12. The multivitamin and mineral composition of claim 10 , wherein the composition further comprises at least one nutritional agent.
13. The multivitamin and mineral composition of claim 12 , wherein the at least one nutritional agent is selected from the group consisting of carotenoids, fiber, phytosterols, glucosides, polyphenols, B complex related compounds, omega-3 fatty acids, probiotics, glucosamine, amino acids, peptides, and combinations thereof.
14. The multivitamin and mineral composition of claim 10 , wherein the composition is a direct compression composition.
15. The multivitamin and mineral composition of claim 10 , wherein the composition comprises a granulation.
16. A method of lubricating a nutritional supplement composition comprising providing the embedded lubrication matrix of claim 1 , providing a nutritional supplement composition, mixing the embedded lubrication matrix and the nutritional supplement composition, and forming a tablet, wherein the nutritional supplement composition is substantially free of stearate.