IP Library › Granted Patent US 9,883,674
Granted Patent B2
US 9,883,674 · App. 15/603,556 · Granted Feb 6, 2018

Antiparasitic compounds

Inventors: Jason D. Speake (Winston-Salem, NC); Joe B. Perales (Durham, NC); Weiming Fan (Chapel Hill, NC); Solene Clarisse Rolland (Lyons, FR)
Assignee: Avista Pharma Solutions, Inc.
A01N43/90A01N43/80C07D491/107
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Quick Facts
Patent No.
US 9,883,674
App. No.
15/603,556
Granted
Feb 6, 2018
Kind
B2
Abstract

The present invention relates to isothiazoline compounds of formula (I). The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to veterinary compositions comprising said compounds.

Claims (5)

1. A method for controlling parasites at a locus comprising applying a compound 1-[6-[5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]spiro[1H-isobenzofuran-3,3′-azetidine]-1′-yl]-3,3,3-trifluoro-propan-1-one or a pesticidal, veterinary, or pharmaceutically acceptable salt thereof to the locus in an effective amount.

2. The method of claim 1 , wherein the parasite is a flea or tick.

3. The method of claim 1 , wherein the parasite is Ctenocephalides fells, R. sanguineus, D. variablis, A. americanum , or I. scapularis.

4. The method of claim 1 , wherein the parasite is a helminth.

5. The method of claim 1 , wherein the parasite is Dirofilaria immitis.

Assignments (6)
RELEASE OF FIRST LIEN SECURITY INTEREST IN PATENTS Recorded Mar 6, 2025
From: ROYAL BANK OF CANADA
To: CAMBREX CHARLES CITY, INC.; AVISTA PHARMA SOLUTIONS, INC.; SNAPDRAGON CHEMISTRY, INC.
Reel/Frame 070438/0333 →
RELEASE OF SECOND LIEN SECURITY INTEREST IN PATENTS Recorded Dec 7, 2020
From: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
To: AVISTA PHARMA SOLUTIONS, INC.
Reel/Frame 054630/0307 →
SECOND LIEN PATENT SECURITY AGREEMENT Recorded Dec 4, 2019
From: CAMBREX CHARLES CITY, INC.; AVISTA PHARMA SOLUTIONS, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 051196/0080 →
NOTICE OF RELEASE OF SECURITY INTEREST IN PATENTS Recorded Dec 4, 2019
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: AVISTA PHARMA SOLUTIONS, INC.
Reel/Frame 051196/0092 →
FIRST LIEN PATENT SECURITY AGREEMENT Recorded Dec 4, 2019
From: AVISTA PHARMA SOLUTIONS, INC.; CAMBREX CHARLES CITY, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 051283/0877 →
SECURITY INTEREST Recorded Feb 1, 2019
From: AVISTA PHARMA SOLUTIONS, INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 048218/0762 →
Continuity (4)
Continuation 15211062 · Jul 15, 2016
Continuation 14995547 · Jan 14, 2016
Provisional Application 62104364 · Jan 16, 2015
Related Publication 20170258089A1 · Sep 14, 2017