METHODS OF TREATMENT OF ACNE VULGARIS USING TOPICAL DAPSONE COMPOSITIONS
Dapsone compositions can be useful for treating acne. The methods and formulations disclosed herein show efficacy for treating acne vulgaris and/or post inflammatory hyperpigmentation.
1 . A method of treating acne vulgaris in a subject in need thereof, the method comprising:
administering a topical pharmaceutical gel composition comprising about 7.5% w/w dapsone to the entire face of the subject at a frequency of once a day for at least 4 weeks;
wherein the method is therapeutically effective to reduce the number of lesions on the face of the subject; and
wherein the topical pharmaceutical gel composition does not comprise adapalene.
2 . The method of claim 1 , wherein the topical pharmaceutical gel composition is administered for at least 8 weeks.
3 . The method of claim 1 , wherein the topical pharmaceutical gel composition is administered for at least 12 weeks.
4 . The method of claim 3 , wherein the lesions comprise inflammatory lesions.
5 . The method of claim 4 , wherein the method is effective o reduce inflammatory lesions by 56%.
6 . The method of claim 3 , wherein the lesions comprise non-inflammatory lesions.
7 . The method of claim 6 , wherein the method is effective to reduce non-inflammatory lesions by 45%.
8 . The method of claim 3 , wherein the method is effective to reduce the amount of local cutaneous irritation in the subject over the treatment duration.
9 . The method of claim 8 , wherein the local cutaneous irritation comprises erythema.
10 . The method of claim 8 , wherein the local cutaneous irritation comprises scaling.
11 . The method of claim 8 , wherein the local cutaneous irritation comprises dryness.
12 . The method of claim 8 , wherein the local cutaneous irritation comprises stinging/burning.