Substituted carbonucleoside derivatives useful as anticancer agents
View Patent ↗Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 and N(R 4 ) 2 ;
R 2 is hydrogen, halogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy or N(R 5 ) 2 , where each R 5 is independently hydrogen or (C 1 -C 8 )alkyl, or two R 5 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
each R 3 is independently selected from hydrogen, hydroxy, NH 2 ; (C 1 -C 8 )alkyl or heteroalkyl having 1-8 atoms, or when D is C(R 3 ) 2 , R 3 is additionally selected from fluorine, (C 1 -C 8 )alkylene or heteroalkylene bound to an atom on G to form a ring fused to G, where R 3 is optionally substituted with 1-6 R 8 ;
each R 9 is independently hydrogen or fluorine;
D is C(R 3 ) 2 , NR 3 , O, S or S(O) 1-2 ;
G is a (C 5 -C 12 )aryl ring system or a 5-12 membered heteroaryl ring system, wherein said (C 5 -C 12 )aryl ring system or a 5-12 membered heteroaryl ring system is fused to (C 3 -C 10 )cycloalkyl or heterocyclyl ring system;
each R 8 is absent or is independently selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 , N(R 4 ) 2 , CN, halogen and CON(R 4 ) 2 , where two R 8 optionally join to form a 4-6 membered spiro-cycloalkyl ring, a cycloalkyl fused ring, or an alkylene bridge spanning G, and where two R 8 optionally join to form carbonyl;
each R 4 is independently A-R 14 , where A is absent, (C 1 -C 3 )alkyl, —C(O)— or —SO 2 —, and R 14 is hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl or 3-12 membered heterocyclyl, or two R 4 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
Q is absent or is a divalent moiety selected from O, S, NH and (C 1 -C 8 )alkylene;
R 10 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, halogen, SH, S—(C 1 -C 8 )alkyl and N(R 11 ) 2 where each R 11 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl; and
R 12 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, fluoro, chloro, bromo, iodo, SH, S—(C 1 -C 8 )alkyl and N(R 13 ) 2 where each R 13 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl.
2. A compound of formula (II):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 and N(R 4 ) 2 ;
R 2 is hydrogen, halogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy or N(R 5 ) 2 , where each R 5 is independently hydrogen or (C 1 -C 8 )alkyl, or two R 5 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
each R 3 is independently selected from hydrogen, hydroxy, NH 2 ; (C 1 -C 8 )alkyl or heteroalkyl having 1-8 atoms, or when D is C(R 3 ) 2 , R 3 is additionally selected from fluorine, (C 1 -C 8 )alkylene or heteroalkylene bound to an atom on G to form a ring fused to G, where R 3 is optionally substituted with 1-6 R 8 ;
each R 9 is independently hydrogen or fluorine;
D is C(R 3 ) 2 , O, or S(O) 1-2 ;
G is a (C 5 -C 12 )aryl, or a 5-12 membered heteroaryl, ring system;
R 15 is heteroalkyl having 1-8 atoms bound to an atom on G and optionally substituted with 1-6 R 8 , or R 15 is heteroalkylene bound to an atom on G, optionally substituted with 1-6 R 8 , and bound to an adjacent atom on G;
each R 8 is absent or is independently selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 , N(R 4 ) 2 , CN, halogen and CON(R 4 ) 2 , where two R 8 optionally join to form a 4-6 membered spiro-cycloalkyl ring, a cycloalkyl fused ring, or an alkylene bridge spanning G, and where two R 8 optionally join to form carbonyl;
each R 4 is independently A-R 14 , where A is absent, (C 1 -C 3 )alkyl, —C(O)— or —SO 2 —, and R 14 is hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl or 3-12 membered heterocyclyl, or two R 4 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
Q is absent or is a divalent moiety selected from O, S, NH and (C 1 -C 8 )alkylene;
R 10 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, halogen, SH, S—(C 1 -C 8 )alkyl and N(R 11 ) 2 where each R 11 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl; and
R 12 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, fluoro, chloro, bromo, iodo, SH, S—(C 1 -C 8 )alkyl and N(R 13 ) 2 where each R 13 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl;
provided that D is S(O) 1-2 when G is C 10 aryl or a 10-membered heteroaryl.
3. A compound of formula (III):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is independently selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 and N(R 4 ) 2 ;
R 2 is hydrogen, halogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy or N(R 5 ) 2 , where each R 5 is independently hydrogen or (C 1 -C 8 )alkyl, or two R 5 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
each R 3 is independently hydrogen, hydroxy or NH 2 ; or when D is C(R 3 ) 2 , R 3 is additionally selected from fluorine;
each R 9 is independently hydrogen or fluorine;
D is C(R 3 ) 2 , O, or S(O) 1-2 ;
E is NR 1 , CH 2 , C(R 1 ) 2 , O or —S(O) 2 ;
each R 8 is absent or is independently selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 , N(R 4 ) 2 , CN, halogen and CON(R 4 ) 2 , where two R 8 optionally join to form a 4-6 membered spiro-cycloalkyl ring, or a cycloalkyl fused ring, and where two R 8 optionally join to form carbonyl;
each R 4 is independently A-R 14 , where A is absent, (C 1 -C 3 )alkyl, —C(O)— or —SO 2 —, and R 14 is hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl or 3-12 membered heterocyclyl, or two R 4 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S; and
Q is absent or is a divalent moiety selected from O, S, NH and (C 1 -C 8 )alkylene;
R 10 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, halogen, SH, 5-(C 1 -C 8 )alkyl and N(R 11 ) 2 where each R 11 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl; and
R 12 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, fluoro, chloro, bromo, SH, S—(C 1 -C 8 )alkyl and N(R 13 ) 2 where each R 13 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl.
4. A compound of formula (IV):
or a pharmaceutically acceptable salt thereof, wherein:
each R 1 is independently selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 and N(R 4 ) 2 ;
R 2 is hydrogen, halogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy or N(R 5 ) 2 , where each R 5 is independently hydrogen or (C 1 -C 8 )alkyl, or two R 5 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
each R 3 is independently hydrogen, hydroxy or NH 2 ; or when D is C(R 3 ) 2 , R 3 is additionally selected from fluorine;
each R 9 is independently hydrogen or fluorine;
B is N or C;
E is NR 1 , CH 2 , C(R 1 ) 2 , O or —S(O) 2 ;
each R 8 is absent or is independently selected from the group consisting of (C 1 -C 8 )alkyl, (C 1 -C 8 )haloalkyl, hydroxy, (C 1 -C 8 )alkoxy, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl, 3-12 membered heterocyclyl, OR 4 , SR 4 , N(R 4 ) 2 , CN, halogen and CON(R 4 ) 2 , where two R 8 optionally join to form a 4-6 membered spiro-cycloalkyl ring, or a cycloalkyl fused ring, and where two R 8 optionally join to form carbonyl;
each R 4 is independently A-R 14 , where A is absent, (C 1 -C 3 )alkyl, —C(O)— or —SO 2 —, and R 14 is hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl, 5-12 membered heteroaryl, (C 3 -C 10 )cycloalkyl or 3-12 membered heterocyclyl, or two R 4 join to form a 4-6 membered heterocyclic ring containing 1-3 heteroatoms selected from N, O and S;
Q is absent or is a divalent moiety selected from O, S, NH and (C 1 -C 8 )alkylene
R 10 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, halogen, SH, (C 1 -C 8 )alkyl and N(R 11 ) 2 where each R 11 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl; and
R 12 is independently selected from hydrogen, (C 1 -C 8 )alkyl, hydroxy, (C 1 -C 8 )alkoxy, fluoro, chloro, bromo, SH, S—(C 1 -C 8 )alkyl and N(R 13 ) 2 where each R 13 is independently hydrogen, (C 1 -C 8 )alkyl, (C 5 -C 12 )aryl or 5-12 membered heteroaryl.
5. The compound or pharmaceutically acceptable salt of claim 3 , wherein:
is selected from:
6. The compound or pharmaceutically acceptable salt of claim 5 , wherein:
is:
7. A compound selected from:
or a pharmaceutically acceptable salt thereof.
8. A compound selected from:
or a pharmaceutically acceptable salt thereof.
9. A compound selected from:
or a pharmaceutically acceptable salt thereof.
10. A compound of any of claims 1 - 4 and 7 - 9 , wherein said salt is selected from acetate, aspartate, benzoate, besylate, bicarbonate, carbonate, bisulphate, sulfate, borate, camsylate, citrate, edisylate, esylate, formate, fumarate, gluceptate, gluconate, glucuronate, hexafluorophosphate, hibenzate, hydrochloride, chloride, hydrobromide, bromide, hydroiodide, iodide, isethionate, lactate, malate, maleate, malonate, mesylate, methylsulfate, naphthylate, 2-napsylate, nicotinate, nitrate, orotate, oxalate, palmitate, pamoate, phosphate, hydrogen phosphate, dihydrogen phosphate, saccharate, stearate, succinate, tartrate, tosylate, trifluoroacetate, aluminum, arginine, benzathine, calcium, choline, diethylamine, diolamine, glycine, lysine, magnesium, meglumine, olamine, potassium, sodium, tromethamine and zinc salts.
11. A compound of any of claims 1 - 4 and 7 - 9 , wherein said salt is selected from hydrochloride, tosylate and mesylate salts.
12. A pharmaceutical composition comprising a compound according to any one of claims 1 - 4 and 7 - 9 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
13. The compound: (1S,2S,3S,5R)-3-((6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, having the structure:
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 13 , wherein said salt is selected from acetate, aspartate, benzoate, besylate, bicarbonate, carbonate, bisulphate, sulfate, borate, camsylate, citrate, edisylate, esylate, formate, fumarate, gluceptate, gluconate, glucuronate, hexafluorophosphate, hibenzate, hydrochloride, chloride, hydrobromide, bromide, hydroiodide, iodide, isethionate, lactate, malate, maleate, malonate, mesylate, methylsulfate, naphthylate, 2-napsylate, nicotinate, nitrate, orotate, oxalate, palmitate, pamoate, phosphate, hydrogen phosphate, dihydrogen phosphate, saccharate, stearate, succinate, tartrate, tosylate, trifluoroacetate, aluminum, arginine, benzathine, calcium, choline, diethylamine, diolamine, glycine, lysine, magnesium, meglumine, olamine, potassium, sodium, tromethamine and zinc salts.
15. A pharmaceutical composition comprising the compound: (1S,2S,3S,5R)-3-((6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, having the structure:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
16. A compound of any of claims 1 - 4 and 7 - 9 , wherein said salt is selected from phosphate, hydrogen phosphate and dihydrogen phosphate.
17. A compound of any of claims 13 - 14 , wherein said salt is selected from phosphate, hydrogen phosphate and dihydrogen phosphate.