Use of aerosolized levofloxacin for treating cystic fibrosis
Methods for treating cystic fibrosis. The method includes administering to a human in need thereof an aerosol solution comprising levofloxacin or ofloxacin and a divalent or trivalent cation. More particularly, the method includes administering the aerosol solution to a human having a pulmonary infection comprising P. aeruginosa.
1. A method for treating a pulmonary Pseudomonas aeruginosa infection in a human in need thereof, the method comprising administering via inhalation 240 mg of levofloxacin twice daily for 28 days to the human to treat the pulmonary Pseudomonas aeruginosa infection; wherein the levofloxacin is in a solution comprising 90 mg/ml to 110 mg/ml of levofloxacin and 175 mM to 225 mM of a magnesium cation.
2. The method of claim 1 , wherein the magnesium cation is in the form of magnesium chloride.
3. The method of claim 2 , wherein the solution comprises 100 mg/ml of levofloxacin and 200 mM of magnesium chloride.
4. The method of claim 1 , wherein the magnesium cation is in the form of magnesium sulfate.
5. The method of claim 1 , wherein the solution is administered by a vibrating mesh nebulizer.
6. The method of claim 1 , wherein the solution has a pH from 5 to 7, and an osmolality from 300 mOsmol/kg to 500 mOsmol/kg.
7. The method of claim 1 , further comprising administering dornase alpha, azithromycin, salbutamol, pancrelipase, sodium chloride, seretide, vitamin A, vitamin D, vitamin E, vitamin K, or a combination of two or more thereof.
8. The method of claim 1 , wherein the human is a pediatric patient.
9. The method of claim 1 , wherein the human has cystic fibrosis.
10. A method for treating a pulmonary Pseudomonas aeruginosa infection in a human in need thereof, the method comprising administering via inhalation 240 mg of levofloxacin twice daily for 28 days to the human to treat the pulmonary Pseudomonas aeruginosa infection; wherein the levofloxacin is in a solution comprising 90 mg/ml to 125 mg/ml of levofloxacin and 150 mM to 250 mM of a cation, wherein the cation is a magnesium cation, a calcium cation, a zinc cation, a copper cation, an aluminum cation, or an iron cation.
11. The method of claim 10 , wherein the cation is the zinc cation.
12. The method of claim 11 , wherein the zinc cation is in the form of zinc chloride.
13. The method of claim 10 , wherein the cation is the copper cation.
14. The method of claim 13 , wherein the copper cation is in the form of copper chloride.
15. The method of claim 10 , wherein the cation is the magnesium cation.
16. The method of claim 15 , wherein the magnesium cation is in the form of magnesium chloride.
17. The method of claim 15 , wherein the magnesium cation is in the form of magnesium sulfate.
18. The method of claim 10 , wherein the solution has a pH from 5 to 7, and an osmolality from 300 mOsmol/kg to 500 mOsmol/kg.
19. The method of claim 10 , wherein the human is a pediatric patient.
20. The method of claim 19 , wherein the pediatric patient has cystic fibrosis.