Composition of bacteroides thetaiotaomicron for immune modulation
The present invention provides a strain of Bacteroides thetaiotaomicron and derivatives thereof, and the use of said strain or derivatives in treating inflammatory, autoimmune and allergic disorders. The invention also provides pharmaceutical compositions, nutritional supplements, feedstuffs, food products, dietary supplements, and food additives comprising said strain or derivatives.
1. A pharmaceutical composition that comprises:
(a) an amount of a Bacteroides thetaiotaomicron bacteria strain deposited under accession number NCIMB 42341, wherein said amount comprises from about 1×10 3 to about 1×10 12 CFU/g of said Bacteroides thetaiotaomicron bacteria strain with respect to the total weight of the pharmaceutical composition, wherein the Bacteroides thetaiotaomicron bacteria strain is live and viable; and
(b) a pharmaceutically acceptable excipient, carrier or diluent;
wherein said pharmaceutical composition is a lyophilized composition.
2. The pharmaceutical composition of claim 1 , wherein said pharmaceutical composition strain is encapsulated.
3. The pharmaceutical composition of claim 1 , wherein said pharmaceutical composition is formulated for oral delivery.
4. The pharmaceutical composition of claim 3 , wherein said pharmaceutical composition comprises an enteric coating.
5. The pharmaceutical composition of claim 1 , wherein said amount comprises from about 1×10 6 to about 1×10 12 CFU/g of said Bacteroides thetaiotaomicron bacteria strain with respect to a total weight of the pharmaceutical composition.
6. The pharmaceutical composition of claim 1 , wherein said pharmaceutical composition further comprises at least one prebiotic compound.
7. The pharmaceutical composition of claim 6 , wherein said at least one prebiotic compound is selected from the group consisting of, inulin, a transgalacto-oligosaccharide, a fructo-oligosaccharide, a chitosan-oligosaccharide, an isomaltooligosaccharide, a pectin, a xylo-oligosaccharide, a beta-glucan, an arable gum modified starch, polydextrose, D-tagatose, acacia fiber, carob, oats, a citrus fiber, and any combination thereof.
8. The pharmaceutical composition of claim 1 , wherein said amount comprises from about 1×10 8 to about 1×10 10 CFU/g of said Bacteroides thetaiotaomicron bacteria strain with respect to a total weight of the pharmaceutical composition.
9. The pharmaceutical composition of claim 1 , in the form of a tablet, capsule or powder.
10. The pharmaceutical composition of claim 1 , further comprising an additional bacteria strain.
11. The pharmaceutical composition of claim 10 , wherein the additional bacteria strain is Roseburia hominis.
12. The pharmaceutical composition of claim 1 , wherein said pharmaceutical composition is formulated for enteral delivery.
13. The pharmaceutical composition of claim 1 , wherein said pharmaceutical composition is formulated for rectal delivery.
14. The pharmaceutical composition of claim 1 , comprising the pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier is lactose, starch, glucose, methyl cellulose, magnesium stearate, mannitol, or sorbitol.