Decarboxylation of cannabidiolic acid in hemp biomass and hemp extract
Provided is a decarboxylating carboxylic acids of cannabinoids in hemp extract or hemp biomass in which the hemp extract or hemp biomass is heated to a temperature of 40° C. to 100° C. in the presence of one or more divalent or monovalent reagents.
1. A method for decarboxylating carboxylic acids of cannabinoids in hemp extract or hemp biomass which comprises heating the hemp extract or hemp biomass to a temperature of 40° C. to 100° C. in the presence of one or more divalent or monovalent reagents.
2. The method of claim 1 , wherein the carboxylic acids of cannabinoids are selected from the group consisting of cannabidolic acid, tetrahydrocannabonolic acid, and mixtures thereof.
3. The method of claim 1 , wherein the hemp extract comprises a super critical CO 2 extract or a Liquid CO 2 extract of hemp or a hemp biomass.
4. The method of claim 1 , wherein the hemp extract comprises an organic solvent extract of hemp or a hemp biomass.
5. The method of claim 4 , wherein the organic solvent extract comprises an alcohol extract or a hexane extract of hemp or a hemp biomass.
6. The method of claim 5 , wherein the alcohol comprises a lower alcohol selected from the group consisting of methanol, ethanol, propanol and butanol.
7. The method of claim 6 , wherein the alcohol is ethanol.
8. The method of claim 1 , wherein the reagent used to perform the decarboxylation is selected from the group consisting of a divalent metal oxide, a divalent metal hydroxide, and divalent metal salts, and a mixture thereof.
9. The method of claim 8 , wherein the reagent is selected from the group consisting of MgO, CaO, ZnO, Mg(OH) 2 , Ca(OH) 2 , CaCl 2 , MgSO4, MgSO4(H 2 O) 7 , and ZnSO4 and a mixture thereof.
10. The method of claim 1 , wherein a reagent used to perform the decarboxylation is selected from the group consisting of a sodium, a potassium and a lithium monovalent salt or hydroxide, and a mixture thereof.
11. The method of claim 9 , wherein the monovalent salt is selected from the group consisting of Na 2 SO 4 , K 2 SO 4 , Li 2 SO 4 , NaOH, KOH, and LiOH, and a mixture thereof.
12. The method of claim 1 , wherein the temperature is from is 50° C. to 80° C.
13. The method of claim 1 , wherein the temperature is from 60° C. to 75° C.
14. The method of claim 1 , wherein the hemp extract of hemp biomass is heated in the presence of one or more divalent or monovalent reagents and water.
15. The method of claim 1 , wherein the hemp extract or hemp biomass is heated in the presence of one or more divalent or monovalent reagents in the absence of water.