IP Library Granted Patent US 10,350,333
Granted Patent B2
US 10,350,333 · App. 15/634,269 · Granted Jul 16, 2019

Stents having bioabsorable layers

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Quick Facts
Patent No.
US 10,350,333
App. No.
15/634,269
Granted
Jul 16, 2019
Kind
B2
Abstract

Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Claims (14)

1. A device comprising:

a. a substrate consisting essentially of layers of polymer and layers of pharmaceutical agent;

b. a plurality of layers deposited directly on said substrate, wherein a first layer comprises a first bioabsorbable polymer, a second layer comprises a layer of a first pharmaceutical agent, a third layer comprises a second bioabsorbable polymer, a fourth layer comprises a layer of said first pharmaceutical agent, and a fifth layer comprises a third bioabsorbable polymer,

wherein said device has a first pharmaceutical agent content of about 1 μg/mm to about 15 μg/mm, and

wherein at least a portion of the first pharmaceutical agent is in crystalline form.

2. The device of claim 1 , wherein said first, second, and third bioabsorbable polymers comprise the same bioabsorbable polymer.

3. The device of claim 1 , wherein said first, second, and third bioabsorbable polymers comprise different bioabsorbable polymers.

4. The device of claim 1 , wherein 5% to 25% of the first pharmaceutical agent is eluted one day after the device is contacted with elution media.

5. The device of claim 1 , wherein 15% to 45% of the first pharmaceutical agent is eluted 7 days after the device is contacted with elution media.

6. The device of claim 1 , wherein 25% to 60% of the first pharmaceutical agent is eluted 14 days after the device is contacted with elution media.

7. The device of claim 1 , wherein 35% to 70% of the first pharmaceutical agent is eluted 21 days after the device is contacted with elution media.

8. The device of claim 1 , wherein said substrate comprises a stent.

9. The device of claim 1 , wherein said first pharmaceutical agent comprises an antiproliferative agent.

10. The device of claim 7 , wherein said antiproliferative agent is a limus drug or paclitaxel.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 7, 2023
From: MT ACQUISITION HOLDINGS LLC
To: MICELL MEDTECH INC.
Reel/Frame 064829/0447 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2022
From: MICELL SPV EQUITY LLC; MICELL SPV I LLC
To: MT ACQUISITION HOLDINGS LLC
Reel/Frame 059075/0462 →
NUNC PRO TUNC ASSIGNMENT Recorded Oct 22, 2021
From: MICELL TECHNOLOGIES, INC.
To: MICELL SPV EQUITY LLC; MICELL SPV I LLC
Reel/Frame 057876/0799 →
SECURITY INTEREST Recorded Jan 11, 2019
From: MICELL TECHNOLOGIES, INC.
To: MICELL SPV I LLC
Reel/Frame 048046/0907 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2017
From: MCCLAIN, JAMES B.; TAYLOR, DOUGLAS
To: MICELL TECHNOLOGIES, INC.
Reel/Frame 043942/0388 →