Treatment of ischemia

1. A method of manufacturing a medicament for treatment of ischemia, comprising:

combining an effective amount of an acid sensing ion channel 1a (ASIC1a) inhibitor with a vehicle to produce a medicament for administration to an ischemic subject for treatment of ischemia.

2. The method of claim 1 , wherein the ASIC1a inhibitor selectively inhibits ASIC1a relative to one or more other acid sensing ion channel (ASIC) family members.

3. The method of claim 1 , wherein the ASIC1a inhibitor is PcTx1 (SEQ ID NO: 1).

4. The method of claim 1 , wherein the ASIC1a inhibitor selectively inhibits ASIC1a relative to every other member of the ASIC family.

5. The method of claim 1 , wherein the ASIC1a inhibitor is selected from the group consisting of SEQ ID NO:2, SEQ NO:3, SEQ ID NO:4 and SEQ ID NO:5.

6. The method of claim 5 , wherein the ASIC1a inhibitor is a peptide having an amino acid sequence of SEQ ID NO:2.

7. The method of claim 5 , wherein the ASIC1a inhibitor is a peptide having an amino acid sequence of SEQ ID NO:3.

8. The method of claim 5 , wherein the ASIC1a inhibitor is a peptide having an amino acid sequence of SEQ NO:4.

9. The method of claim 5 , wherein the ASIC1a inhibitor is a peptide having an amino acid sequence of SEQ ID NO:5.

10. The method of claim 1 , wherein the ASIC1a inhibitor is a peptide having a cystine knot.