Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
1. A foamable composition formulated for skin delivery of an active agent comprising:
a minocycline in a therapeutically effective amount of about 1 to about 5% by weight of the composition;
a short chain alcohol comprising ethanol;
about 12% to about 30% by weight of the composition of a protic polar solvent comprising propylene glycol;
a polymeric agent comprising a cellulose ether;
a modulating agent comprises an antioxidizing agent;
a metal;
an essential oil;
wherein the foamable composition is surfactant free;
and wherein the composition is waterless and essentially free of fatty alcohol.
2. The foamable composition according to claim 1 , wherein the minocycline is a minocycline hydrochloride.
3. The foamable composition according to claim 1 , wherein the therapeutically effective amount is about 1%.
4. The foamable composition according to claim 1 , wherein the therapeutically effective amount is about 4%.
5. The foamable composition according to claim 1 , wherein the short chain alcohol is present in an amount of at least 55% by weight of the composition.
6. The foamable composition according to claim 1 , wherein the cellulose ether is a hydroxypropyl cellulose.
7. The foamable composition according to claim 1 , wherein the modulating agent is present in an amount ranging from about 0.1% to about 10% by weight of the composition.
8. The foamable composition according to claim 7 , wherein the modulating agent is present in an amount ranging from about 1% to about 5% by weight of the composition.
9. The foamable composition according to claim 1 , wherein the cellulose ether is present in an amount ranging from about 0.5% to about 1% by weight of the composition.
10. The foamable composition according to claim 1 , wherein:
the minocycline is minocycline hydrochloride; and
the cellulose ether is a hydroxypropyl cellulose.
11. The foamable composition according to claim 10 , wherein:
the ethanol is present in an amount of at least 55% by weight of the composition;
the hydroxypropyl cellulose is present in an amount of about 0.5% to about 1% by weight of the composition; and
the modulating agent is present in an amount ranging from about 0.1% to about 10% by weight of the composition.
12. The foamable composition according to claim 11 , wherein the therapeutically effective amount is about 1% by weight of the composition.
13. The foamable composition according to claim 11 , wherein the therapeutically effective amount is about 4% by weight of the composition.
14. The foamable composition according to claim 1 , wherein the liquefied or compressed gas propellant is present in an amount ranging from about 3% to about 25% by weight of the composition.