Extracellular Matrix Structures
A tissue prosthesis comprising an extracellular matrix (ECM) composition, the ECM composition comprising decellularized ECM derived from mesothelial tissue and an exogenously added basic fibroblast growth factor (bFGF).
1 . A tissue prosthesis, comprising:
a remodelable sheet structure comprising an extracellular matrix (ECM) composition, said ECM composition comprising decellularized ECM derived from mesothelial tissue and an exogenously added basic fibroblast growth factor (bFGF),
said sheet structure being configured to induce modulated healing of tissue when delivered to damaged tissue, said modulated healing including induced host tissue proliferation, bioremodeling of said damaged tissue, and regeneration of tissue structures with site-specific structural and functional properties.
2 . The tissue prosthesis of claim 1 , wherein said ECM composition includes an additional biologically active agent.
3 . The tissue prosthesis of claim 2 , wherein said biologically active agent comprises a growth factor selected from the group consisting of transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-β), basic fibroblast growth factor (bFGF), and vascular epithelial growth factor (VEGF).
4 . The tissue prosthesis of claim 2 , wherein said biologically active agent comprises a cell selected from the group consisting of a stem cell, cardiomyocyte, myofibroblast, mesenchymal stem cell, exogenous cell, endogenous cell, progenitor cell and macrophage.