Targeted conjugates and particles and formulations thereof
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
1. A method of inhibiting cancer cell proliferation in a subject comprising administering to the subject a conjugate having a structure of
or its salt, or a pharmaceutical composition comprising said conjugate or its salt and at least one pharmaceutically acceptable carrier or excipient, wherein the cancer cell is a lung cancer cell.
2. The method of claim 1 , wherein the lung cancer cell is a small cell lung cancer cell.
3. The method of claim 1 , wherein the rate of cellular proliferation is inhibited, cellular proliferation is prevented, and/or cell death is induced.
4. A method of inhibiting the rate of growth of a tumor, the size of a tumor or the volume of a tumor, the method comprising contacting the tumor with a conjugate having a structure of
or its salt, or a pharmaceutical composition comprising said conjugate or its salt and at least one pharmaceutically acceptable carrier or excipient, wherein the tumor is a lung tumor.
5. The method of claim 4 , wherein the lung tumor is small cell lung cancer.