IP Library › Granted Patent US 10,669,240

Granted Patent B2

US 10,669,240 · App. 15/653,747 · Granted Jun 2, 2020

5-substituted indazole-3-carboxamides and preparation and use thereof

Inventors: John Hood (San Diego, CA); Sunil Kumar KC (San Diego, CA); David Mark Wallace (San Diego, CA); Gopi Kumar Mittapalli (San Diego, CA); Brian Joseph Hofilena (San Diego, CA); Chi Ching Mak (San Diego, CA); Venkataiah Bollu (San Diego, CA); Brian Eastman (San Diego, CA)

Assignee: Samumed, LLC

C07D231/56 C07B59/002 C07D401/04 C07D401/12 C07D401/14 C07D405/12 C07D405/14 C07D498/08

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 10,669,240
App. No.: 15/653,747
Granted: Jun 2, 2020
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Claims (925)

1. A compound, or pharmaceutically acceptable salt thereof, of Formula I:

wherein:

R 1 is selected from the group consisting of H, and halide;

R 2 is 6-membered heteroaryl(R 4 );

R 3 is selected from the group consisting of —(C 1-6 alkyl)N(R 68 ) 2 , -monocyclic heterocyclyl(R 8 ) p , -spirocyclic heterocyclyl(R 8 ) p , —(C 1-3 alkyl)heterocyclyl(R 9 ) p ,

R 4 is 1 substituent attached to the 6-membered heteroaryl(R 4 ) and is selected from the group consisting of —(C 1-3 alkyl) n (4-7-membered)heterocyclyl(R 22 ) p , —NHC(═O)R 24 , and —(C 1-6 alkyl) n N(R 25 ) 2 ;

each R 7 is a substituent attached to the carbocyclyl ring and is independently selected at each occurrence from the group consisting of H, halide, and —N(R 25 ) 2 ;

each R 8 is a substituent attached to the heterocyclyl ring and is independently selected at each occurrence from the group consisting of H, halide, —(C 1-3 alkyl)carbocyclyl(R 7 ) p , —(C 1-3 alkyl)phenyl(R 11 ) q , -heterocyclyl(R 31 ) p , unsubstituted —C 1-6 haloalkyl, and unsubstituted —C 1-6 alkyl;

each R 9 is a substituent attached to the heterocyclyl ring and is independently selected at each occurrence from the group consisting of H, halide, unsubstituted —C 1-6 haloalkyl, and unsubstituted —C 1-6 alkyl;

each R 11 is a substituent attached to the aryl ring and is independently selected at each occurrence from the group consisting of H, and halide;

each R 12 is a substituent attached to the pyridinyl ring and is independently selected at each occurrence from the group consisting of H, halide, and —C 1-6 haloalkyl;

each R 13 is —NHC(═O)R 42 ;

each R 14 is selected from the group consisting of unsubstituted —C 1-6 haloalkyl, and unsubstituted —C 1-6 alkyl;

each R 15 is selected from the group consisting of halide, unsubstituted —C 1-6 alkyl, —OR 43 , and —C(═O)N(R 53 ) 2 ;

each R 17 is a substituent attached to the pyridinyl ring and is independently selected at each occurrence from the group consisting of —C 1-6 haloalkyl, —OR 34 , and —(C 1-3 alkyl) n heterocyclyl(R 36 ) p ; wherein heterocyclyl is selected from the group consisting of azetidinyl, pyrrolidinyl, piperidinyl, and piperazinyl;

each R 18 is a substituent attached to the heteroaryl ring and is independently selected at each occurrence from the group consisting of halide, and —C 1-6 haloalkyl;

each R 19 is a substituent attached to the heteroaryl ring and is independently selected at each occurrence from the group consisting of halide, —C 1-6 haloalkyl, and —C 1-6 alkyl;

each R 22 is a substituent attached to the heterocyclyl ring and is independently selected at each occurrence from the group consisting of H, halide, —OH, —N(R 25 ) 2 , and —C 1-6 alkyl;

each R 24 is independently selected at each occurrence from the group consisting of —N(R 60 ) 2 , and -carbocyclyl;

each R 25 is independently selected at each occurrence from the group consisting of H and —C 1-6 alkyl, alternatively, two adjacent R 25 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring;

each R 31 is a substituent attached to the heterocyclyl ring and is independently selected at each occurrence from the group consisting of H and halide;

each R 34 is independently selected at each occurrence from the group consisting of H, —C 1-6 alkyl, and -heterocyclyl(R 61 ) p ;

each R 36 is a substituent attached to the heterocyclyl ring and is independently selected at each occurrence from the group consisting of H, halide, and —C 1-6 alkyl;

each R 42 is —C 1-6 alkyl;

each R 43 is independently selected at each occurrence from the group consisting of —C 3-6 alkyl, and -heterocyclyl(R 61 ) p ;

each R 53 is —C 1-4 alkyl;

each R 60 is —C 1-6 alkyl;

each R 61 is a substituent attached to the heterocyclyl ring and is —C 1-6 alkyl;

each R 68 is independently selected at each occurrence from the group consisting of H and unsubstituted —C 1-6 alkyl;

m is an integer of 1 to 4;

each n is independently an integer of 0 to 1;

each p is independently an integer of 1 to 10;

each q is independently an integer of 1 to 5;

t is an integer of 1 to 4;

y is an integer of 1 to 3;

z is an integer of 1 to 5; and

with the proviso that a compound of Formula I is not a compound selected from the group consisting of:

2. The compound of claim 1 , wherein R 1 is selected from the group consisting of H and F.

3. The compound of claim 2 , wherein R 1 is H.

4. The compound of claim 2 , wherein R 1 is F.

5. The compound of claim 3 , wherein R 2 is pyridinyl(R 4 ).

6. The compound of claim 5 , wherein R 2 is pyridin-3-yl(R 4 ).

7. The compound of claim 6 , wherein R 4 is —(C 1-3 alkyl) n (4-7-membered)heterocyclyl(R 22 ) p .

8. The compound of claim 7 , wherein R 4 is -(4-7-membered)heterocyclyl(R 22 ) p .

9. The compound of claim 8 , wherein R 4 is selected from the group consisting of

10. The compound of claim 7 , wherein R 4 is —(CH 2 )(4-7-membered)heterocyclyl(R 22 ) p .

11. The compound of claim 10 , wherein R 4 is selected from the group consisting of

12. The compound of claim 6 , wherein R 3 is -monocyclic heterocyclyl(R 8 ) p .

13. The compound of claim 12 , wherein R 3 is selected from the group consisting of

14. A compound of Formula I having the structure selected from the group consisting of:

N-(1-methylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1];

5-(pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [2];

N-(piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [3];

N-cyclohexyl-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [4];

N-cyclobutyl-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [5];

N-cyclopropyl-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [6];

N-isopropyl-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [7];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [8];

N-cyclopropyl-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [9];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [10];

N-(2,3-dihydro-1H-inden-2-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [22];

N-(2,3-dihydro-1H-inden-2-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [23];

N-(2,3-dihydro-1H-inden-2-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [24];

N-(2,3-dihydro-1H-inden-2-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [25];

N-benzyl-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [26];

N-(1-phenylcyclopropyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [32];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-phenylcyclopropyl)-1H-indazole-3-carboxamide [33];

N-(1-phenylcyclopropyl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [34];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(1-phenylcyclopropyl)-1H-indazole-3-carboxamide [35];

N-(1-phenylcyclopropyl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [36];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(1-phenylcyclopropyl)-1H-indazole-3-carboxamide [37];

N-((1R,2R)-2-phenylcyclopropyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [38];

N-((1R,2R)-2-phenylcyclopropyl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [39];

5-(pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [40];

5-(pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [41];

5-(pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [42];

5-(pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [45];

N-(3,5-difluoropyridin-2-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [46];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [56];

N-(5-fluoropyridin-2-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [57];

N-(3,5-difluoropyridin-2-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [58];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [59];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [60];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [61];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [62];

N-(5-methylpyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [64];

N-(6-methylpyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [65];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [66];

N-(6-isopropoxypyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [67];

N-(6-((1,3-dihydroxypropan-2-yl)oxy)pyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [70];

N-(4-(3-methylbutanamido)pyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [73];

N-(2-methoxypyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [78];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [80];

5-(5-((6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)methyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [85];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [89];

N-(1-isopropylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [90];

N-(1-isobutylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [91];

N-(1-methylpiperidin-4-yl)-5-(6-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [94];

N-(1-methylpiperidin-4-yl)-5-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [95];

N-(2-methylpyrimidin-5-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [97];

N-(2-methylpyrimidin-5-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [98];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [100];

N-(2-(piperidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [101];

5-(pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [102];

N-(2-(piperidin-1-yl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [103];

5-(pyridin-3-yl)-1H-indazole-3-carboxamide [104];

5-(5-aminopyridin-3-yl)-1H-indazole-3-carboxamide [105];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [106];

5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [107];

5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [108];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [109];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [110];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [111];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [112];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [113];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [114];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [115];

5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [116];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [117];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [118];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [119];

5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [120];

5-(5-aminopyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [123];

N-isopropyl-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [124];

N-isopropyl-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [125];

N-isopropyl-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [126];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [127];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [128];

N-isopropyl-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [129];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [130];

N-isopropyl-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [131];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [132];

N-isopropyl-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [133];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [134];

N-isopropyl-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [135];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [136];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [137];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [138];

N-isopropyl-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [139];

5-(5-aminopyridin-3-yl)-N-cyclopropyl-1H-indazole-3-carboxamide [142];

N-cyclopropyl-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [143];

N-cyclopropyl-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [144];

N-cyclopropyl-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [145];

N-cyclopropyl-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [146];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-cyclopropyl-1H-indazole-3-carboxamide [147];

N-cyclopropyl-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide[N-cyclopropyl-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [148];

N-cyclopropyl-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [149];

N-cyclopropyl-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [150];

N-cyclopropyl-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [151];

N-cyclopropyl-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [152];

N-cyclopropyl-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [153];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-cyclopropyl-1H-indazole-3-carboxamide [154];

N-cyclopropyl-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [155];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-cyclopropyl-1H-indazole-3-carboxamide [156];

N-cyclopropyl-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [157];

5-(5-aminopyridin-3-yl)-N-cyclobutyl-1H-indazole-3-carboxamide [160];

N-cyclobutyl-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [161];

N-cyclobutyl-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [162];

N-cyclobutyl-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [163];

N-cyclobutyl-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [164];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-cyclobutyl-1H-indazole-3-carboxamide [165];

N-cyclobutyl-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [166];

N-cyclobutyl-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [167];

N-cyclobutyl-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [168];

N-cyclobutyl-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [169];

N-cyclobutyl-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [170];

N-cyclobutyl-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [171];

N-cyclobutyl-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [172];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-cyclobutyl-1H-indazole-3-carboxamide [173];

N-cyclobutyl-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [174];

N-cyclobutyl-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [175];

N-cyclobutyl-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [176];

N-cyclopentyl-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [179];

5-(5-aminopyridin-3-yl)-N-cyclopentyl-1H-indazole-3-carboxamide [180];

N-cyclopentyl-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [181];

N-cyclopentyl-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [182];

N-cyclopentyl-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [183];

N-cyclopentyl-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [184];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-cyclopentyl-1H-indazole-3-carboxamide [185];

N-cyclopentyl-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [186];

N-cyclopentyl-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [187];

N-cyclopentyl-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [188];

N-cyclopentyl-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [189];

N-cyclopentyl-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [190];

N-cyclopentyl-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [191];

N-cyclopentyl-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [192];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-cyclopentyl-1H-indazole-3-carboxamide [193];

N-cyclopentyl-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [194];

N-cyclopentyl-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [195];

N-cyclopentyl-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [196];

5-(5-aminopyridin-3-yl)-N-cyclohexyl-1H-indazole-3-carboxamide [199];

N-cyclohexyl-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [200];

N-cyclohexyl-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [201];

N-cyclohexyl-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [202];

N-cyclohexyl-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [203];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-cyclohexyl-1H-indazole-3-carboxamide [204];

N-cyclohexyl-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [205];

N-cyclohexyl-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [206];

N-cyclohexyl-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [208];

N-cyclohexyl-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [209];

N-cyclohexyl-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [210];

N-cyclohexyl-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [211];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-cyclohexyl-1H-indazole-3-carboxamide [212];

N-cyclohexyl-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [213];

N-cyclohexyl-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [214];

N-cyclohexyl-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [215];

5-(5-aminopyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [218];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [219];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [220];

5-(5-morpholinopyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [221];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [222];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [223];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [224];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [225];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [227];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [228];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [229];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [230];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [231];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [232];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [233];

5-(5-phenoxypyridin-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-3-carboxamide [234];

5-(5-aminopyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [237];

N-(piperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [238];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [239];

5-(5-morpholinopyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [240];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [241];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [242];

N-(piperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [243];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [244];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [245];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [246];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [247];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [248];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [249];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [250];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [251];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [252];

5-(5-phenoxypyridin-3-yl)-N-(piperidin-4-yl)-1H-indazole-3-carboxamide [253];

5-(5-aminopyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [256];

N-(1-methylpiperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [257];

N-(1-methylpiperidin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [258];

N-(1-methylpiperidin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [259];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [260];

N-(1-methylpiperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [261];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [263];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [264];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [265];

N-(1-methylpiperidin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [266];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [267];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [268];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(1-methylpiperidin-4-yl)-1H-indazole-3-carboxamide [269];

N-(1-methylpiperidin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [270];

5-(5-aminopyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [273];

N-(1-isopropylpiperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [274];

N-(1-isopropylpiperidin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [275];

N-(1-isopropylpiperidin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [276];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [277];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [278];

N-(1-isopropylpiperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [279];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [280];

N-(1-isopropylpiperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [281];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [282];

N-(1-isopropylpiperidin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [283];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [284];

N-(1-isopropylpiperidin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [285];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [286];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [287];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [288];

N-(1-isopropylpiperidin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [289];

N-(1-(tert-butyl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [291];

5-(5-aminopyridin-3-yl)-N-(1-(tert-butyl)piperidin-4-yl)-1H-indazole-3-carboxamide [292];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [293];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [294];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [295];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [296];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-(tert-butyl)piperidin-4-yl)-1H-indazole-3-carboxamide [297];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [298];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [299];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [300];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [301];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [302];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [303];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [304];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-(tert-butyl)piperidin-4-yl)-1H-indazole-3-carboxamide [305];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [306];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [307];

N-(1-(tert-butyl)piperidin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [308];

5-(5-aminopyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [311];

N-(1-isobutylpiperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [312];

N-(1-isobutylpiperidin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [313];

N-(1-isobutylpiperidin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [314];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [315];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [316];

N-(1-isobutylpiperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [317];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [318];

N-(1-isobutylpiperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [319];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [320];

N-(1-isobutylpiperidin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [321];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [322];

N-(1-isobutylpiperidin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [323];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [324];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [325];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [326];

N-(1-isobutylpiperidin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [327];

N-(1-neopentylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [329];

5-(5-aminopyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [330];

N-(1-neopentylpiperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [331];

N-(1-neopentylpiperidin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [332];

5-(5-morpholinopyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [333];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [334];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [335];

N-(1-neopentylpiperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [336];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [337];

N-(1-neopentylpiperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [338];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [339];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [340];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [341];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [342];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [343];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [344];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(1-neopentylpiperidin-4-yl)-1H-indazole-3-carboxamide [345];

N-(1-neopentylpiperidin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [346];

N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [349];

5-(5-aminopyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [350];

N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [351];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [352];

5-(5-morpholinopyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [353];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [354];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [355];

N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [356];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [357];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [358];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [359];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [360];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [361];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [362];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [363];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [364];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(1-(prop-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [365];

N-(1-isopropylpiperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [366];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [369];

5-(5-aminopyridin-3-yl)-N-(1-(but-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [370];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [371];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [372];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [373];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [374];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(1-(but-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [375];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [376];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [377];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [378];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [379];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [380];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [381];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [382];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(1-(but-2-yn-1-yl)piperidin-4-yl)-1H-indazole-3-carboxamide [383];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [384];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [385];

N-(1-(but-2-yn-1-yl)piperidin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [386];

N-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [389];

5-(5-aminopyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [390];

N-(pyridin-2-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [391];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [392];

5-(5-morpholinopyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [393];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [394];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [395];

N-(pyridin-2-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [396];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [397];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [398];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [399];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [400];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [401];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [402];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [403];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [404];

5-(5-phenoxypyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [405];

5-(pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [408];

5-(5-aminopyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [409];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [410];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [411];

5-(5-morpholinopyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [412];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [413];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [414];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [415];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [416];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [417];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [418];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [419];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [420];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [421];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [422];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [423];

5-(5-phenoxypyridin-3-yl)-N-(3-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [424];

5-(5-aminopyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [427];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [428];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [429];

5-(5-morpholinopyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [430];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [431];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [432];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [433];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [434];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [435];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [436];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [437];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [438];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [439];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [440];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [441];

5-(5-phenoxypyridin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [442];

5-(5-aminopyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [445];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [446];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [447];

5-(5-morpholinopyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [448];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [449];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [450];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [451];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [452];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [453];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [454];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [455];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [456];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [457];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [458];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [459];

5-(5-phenoxypyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [460];

5-(5-aminopyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [463];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [464];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [465];

5-(5-morpholinopyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [466];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [467];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [468];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [469];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [470];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [471];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [472];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [473];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [474];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [475];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [476];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [477];

5-(5-phenoxypyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-3-carboxamide [478];

5-(5-aminopyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [482];

N-(5-fluoropyridin-2-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [483];

N-(5-fluoropyridin-2-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [484];

N-(5-fluoropyridin-2-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [485];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [486];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [487];

N-(5-fluoropyridin-2-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [488];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [489];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [490];

N-(5-fluoropyridin-2-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [491];

N-(5-fluoropyridin-2-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [492];

N-(5-fluoropyridin-2-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [493];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [494];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [495];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(5-fluoropyridin-2-yl)-1H-indazole-3-carboxamide [496];

N-(5-fluoropyridin-2-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [497];

5-(5-aminopyridin-3-yl)-N-(3,5-difluoropyridin-2-yl)-1H-indazole-3-carboxamide [500];

N-(3,5-difluoropyridin-2-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [501];

N-(3,5-difluoropyridin-2-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [502];

N-(3,5-difluoropyridin-2-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [503];

N-(3,5-difluoropyridin-2-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [504];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(3,5-difluoropyridin-2-yl)-1H-indazole-3-carboxamide [505];

N-(3,5-difluoropyridin-2-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [506];

N-(3,5-difluoropyridin-2-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [507];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(3,5-difluoropyridin-2-yl)-1H-indazole-3-carboxamide [508];

N-(3,5-difluoropyridin-2-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [509];

N-(3,5-difluoropyridin-2-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [510];

N-(3,5-difluoropyridin-2-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [511];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(3,5-difluoropyridin-2-yl)-1H-indazole-3-carboxamide [512];

N-(3,5-difluoropyridin-2-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [513];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(3,5-difluoropyridin-2-yl)-1H-indazole-3-carboxamide [514];

N-(3,5-difluoropyridin-2-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [515];

5-(pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [530];

5-(5-aminopyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [531];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [532];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [533];

5-(5-morpholinopyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [534];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [525];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [536];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [537];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [538];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [539];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [540];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [541];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [542];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [543];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [544];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [545];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-H-indazole-3-carboxamide [546];

5-(5-phenoxypyridin-3-yl)-N-(5-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [547];

N-(6-methylpyridin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [550];

5-(5-aminopyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [551];

N-(6-methylpyridin-3-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [552];

N-(6-methylpyridin-3-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [553];

N-(6-methylpyridin-3-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [554];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [555];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [556];

N-(6-methylpyridin-3-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [557];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [558];

N-(6-methylpyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [559];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [560];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [561];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [562];

N-(6-methylpyridin-3-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [563];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [564];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [565];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(6-methylpyridin-3-yl)-1H-indazole-3-carboxamide [566];

N-(6-methylpyridin-3-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [567];

N-(5-methylpyridin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [570];

5-(5-aminopyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [571];

N-(5-methylpyridin-3-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [572];

N-(5-methylpyridin-3-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [573];

N-(5-methylpyridin-3-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [574];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [575];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [576];

N-(5-methylpyridin-3-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [577];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [578];

N-(5-methylpyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [579];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [580];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [581];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [582];

N-(5-methylpyridin-3-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [583];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [584];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-1H-indazole-3-carboxamide [585];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(5-methylpyridin-3-yl)-H-indazole-3-carboxamide [586];

N-(5-methylpyridin-3-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [587];

N-(6-isopropoxypyridin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [606];

5-(5-aminopyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [607];

N-(6-isopropoxypyridin-3-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [608];

N-(6-isobutylpyridin-3-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [609];

N-(6-isopropoxypyridin-3-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [610];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [611];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [612];

N-(6-isopropoxypyridin-3-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [613];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [614];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [615];

N-(6-isopropoxypyridin-3-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [616];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [617];

N-(6-isopropoxypyridin-3-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [618];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [619];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-1H-indazole-3-carboxamide [620];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(6-isopropoxypyridin-3-yl)-H-indazole-3-carboxamide [621];

N-(6-isopropoxypyridin-3-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [622];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [625];

5-(5-aminopyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [626];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [627];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [629];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [630];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [631];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [632];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [633];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [634];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [635];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [636];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [637];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [638];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [639];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [640];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-1H-indazole-3-carboxamide [641];

N-(6-((1-methylpiperidin-4-yl)oxy)pyridin-3-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [642];

5-(5-aminopyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [819];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [820];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [821];

5-(5-morpholinopyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [822];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [823];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [824];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [825];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [826];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [827];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [828];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [829];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [830];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [831];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [832];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [833];

5-(5-phenoxypyridin-3-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [834];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [837];

5-(5-aminopyridin-3-yl)-N-(2-(azetidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [838];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [839];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [840];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [841];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [842];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [843];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [844];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [845];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [846];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [847];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [848];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [849];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [850];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(azetidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [851];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [852];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [853];

N-(2-(azetidin-1-yl)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [854];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [857];

5-(5-aminopyridin-3-yl)-N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [858];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [859];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [860];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [861];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [862];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [863];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [864];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [865];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [866];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [867];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [868];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [869];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [870];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [871];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [872];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [873];

N-(2-(3,3-difluoroazetidin-1-yl)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [874];

5-(5-aminopyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [877];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [878];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [879];

5-(5-morpholinopyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [880];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [881];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [882];

N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [883];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [884];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [885];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [886];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [887];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [888];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [889];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [890];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [891];

5-(5-phenoxypyridin-3-yl)-N-(2-(pyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [892];

N-(2-(3,3 difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [895];

5-(5-aminopyridin-3-yl)-N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [896];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [897];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [898];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [899];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [900];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [901];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [902];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [903];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [904];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [905];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [906];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [907];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [908];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [909];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [910];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [911];

N-(2-(3,3-difluoropyrrolidin-1-yl)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [912];

5-(5-aminopyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [915];

N-(2-(piperidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [916];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [917];

5-(5-morpholinopyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [918];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [919];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [920];

N-(2-(piperidin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [921];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [922];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [923];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [924];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [925];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [926];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [927];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [928];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [929];

5-(5-phenoxypyridin-3-yl)-N-(2-(piperidin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [930];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [933];

5-(5-aminopyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [934];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [935];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [936];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [937];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [938];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [939];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [940];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [941];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [942];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [943];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [944];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [945];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [946];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [947];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [948];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-3-carboxamide [949];

N-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [950];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [953];

5-(5-aminopyridin-3-yl)-N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [954];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [955];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [956];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [957];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [958];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [959];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [960];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl) pyridin-3-yl)-1H-indazole-3-carboxamide [961];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [962];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [963];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [964];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [965];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [966];

-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [967];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(3,3-dimethylureido)pyridin-3-yl)-1H-indazole-3-carboxamide [968];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-1H-indazole-3-carboxamide [969];

N-(2-(azetidin-1-ylmethyl)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [970];

5-(pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [973];

5-(5-aminopyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [974];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [975];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [976];

5-(5-morpholinopyridin-3-yl)-N-(2-(pyrroidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [977];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [978];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [979];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [980];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [981];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [982];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [983];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [984];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [985];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [986];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [987];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [988];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [989];

5-(5-phenoxypyridin-3-yl)-N-(2-(pyrrolidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [990];

N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [993];

5-(5-aminopyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [994];

N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [995];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [996];

5-(5-morpholinopyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [997];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [998];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [999];

N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1000];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1001];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1002];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1003];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1004];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1005];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1006];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1007];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1008];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1009];

5-(5-phenoxypyridin-3-yl)-N-(2-(piperidin-1-ylmethyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1010];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1013];

5-(5-aminopyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1014];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1015];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1016];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [1017];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1018];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1019];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1020];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1021];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1022];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1023];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1024];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1025];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1026];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1027];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1028];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-1H-indazole-3-carboxamide [1029];

N-(2-((4-methylpiperazin-1-yl)methyl)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [1030];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1033];

5-(5-aminopyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1034];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1035];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1036];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [1037];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1038];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1039];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1040];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1041];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1042];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1043];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1044];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1045];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1046];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1047];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1048];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-1H-indazole-3-carboxamide [1049];

N-(2-((1-methylpiperidin-4-yl)oxy)pyridin-4-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [1050];

5-(pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1069];

5-(5-aminopyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1070];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1071];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1072];

5-(5-morpholinopyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1073];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1074];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1075];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1076];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1077];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1078];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1079];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1080];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1081];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1082];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1083];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1084];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(6-(trifluoromethyl)pyridin-3-yl)-H-indazole-3-carboxamide [1085];

5-(5-phenoxypyridin-3-yl)-N-(5-(trifluoromethyl)pyrazin-2-yl)-1H-indazole-3-carboxamide [1086];

5-(5-aminopyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1089];

N-(2-methylpyrimidin-5-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1090];

N-(2-methylpyrimidin-5-yl)-5-(5-(piperidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1091];

N-(2-methylpyrimidin-5-yl)-5-(5-morpholinopyridin-3-yl)-1H-indazole-3-carboxamide [1092];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1093];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1094];

N-(2-methylpyrimidin-5-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1095];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1096];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1097];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1098];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1099];

N-(2-methylpyrimidin-5-yl)-5-(5-(morpholinomethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1100];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1101];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1102];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide [1103];

N-(2-methylpyrimidin-5-yl)-5-(5-phenoxypyridin-3-yl)-1H-indazole-3-carboxamide [1104];

5-(pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1107];

5-(5-aminopyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1108];

5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1109];

5-(5-(piperidin-1-yl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1110];

5-(5-morpholinopyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1111];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1112];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1113];

5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1114];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1115];

5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1116];

5-(5-((4,4-difluoropiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1117];

5-(5-((4-methylpiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1118];

5-(5-((4-hydroxypiperidin-1-yl)methyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1119];

5-(5-(morpholinomethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1120];

5-(5-(azepan-1-ylmethyl)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1121];

5-(5-(3,3-dimethylureido)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1122];

5-(5-(cyclopropanecarboxamido)pyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1123];

5-(5-phenoxypyridin-3-yl)-N-(2-(trifluoromethyl)pyrimidin-5-yl)-1H-indazole-3-carboxamide [1124];

N-(1-benzylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1152];

6-fluoro-N-(1-methylpiperidin-4-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1155];

6-fluoro-N-(1-isopropylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1156];

N-(1-(tert-butyl)piperidin-4-yl)-6-fluoro-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1157];

N-(pentan-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1158];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(pentan-3-yl)-1H-indazole-3-carboxamide [1159];

N-(1-(2-fluoroethyl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1180];

N-(1-(2,2-difluoroethyl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1181];

5-(pyridin-3-yl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-indazole-3-carboxamide [1182];

N-(1-(tert-butyl)azetidin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1183];

N-(1-(2-fluoroethyl)azetidin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1184];

N-(1-(2,2-difluoroethyl)azetidin-3-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1185];

5-(pyridin-3-yl)-N-(1-(2,2,2-trifluoroethyl)azetidin-3-yl)-1H-indazole-3-carboxamide [1186];

N-((1-methylpiperidin-4-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1187];

N-((1-isopropylpiperidin-4-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1188];

N-((1-(tert-butyl)piperidin-4-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1189];

N-((1-isopropylazetidin-3-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1190];

N-((1-(tert-butyl)azetidin-3-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1191];

N-((1-(2-fluoroethyl)azetidin-3-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1192];

N-((1-(2,2-difluoroethyl)azetidin-3-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1193];

5-(pyridin-3-yl)-N-((1-(2,2,2-trifluoroethyl)azetidin-3-yl)methyl)-1H-indazole-3-carboxamide [1194];

5-(pyridin-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)-1H-indazole-3-carboxamide [1195];

N-(2-(3,3-difluoropyrrolidin-1-yl)ethyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1196];

N-(2-(3,3-difluoroazetidin-1-yl)ethyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1197];

N-(tert-butyl)-5-(5-((dimethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1198];

5-(5-((dimethylamino)methyl)pyridin-3-yl)-N-(pentan-3-yl)-1H-indazole-3-carboxamide [1199];

N-(tert-butyl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1200];

N-(pentan-3-yl)-5-(5-(pyrrolidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1201];

N-(tert-butyl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1202];

N-(pentan-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1203];

N-(tert-butyl)-5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1204];

5-(5-((3,3-difluoropyrrolidin-1-yl)methyl)pyridin-3-yl)-N-(pentan-3-yl)-1H-indazole-3-carboxamide [1205];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(tert-butyl)-1H-indazole-3-carboxamide [1206];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-(pentan-3-yl)-1H-indazole-3-carboxamide [1207];

5-(5-((3,3-difluoroazetidin-1-yl)methyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [1208];

N-cyclopropyl-5-(5-((3,3-difluoroazetidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1209];

N-(tert-butyl)-5-(5-((3,3-difluoroazetidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1210];

5-(5-((3,3-difluoroazetidin-1-yl)methyl)pyridin-3-yl)-N-(pentan-3-yl)-1H-indazole-3-carboxamide [1211];

N-cyclopentyl-5-(5-((3,3-difluoroazetidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1212];

N-cyclohexyl-5-(5-((3,3-difluoroazetidin-1-yl)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1213];

N-(tert-butyl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1214];

N-(pentan-3-yl)-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1215];

N-isopropyl-5-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole-3-carboxamide [1245];

5-(5-((diethylamino)methyl)pyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [1246];

5-(5-chloropyridin-3-yl)-N-isopropyl-1H-indazole-3-carboxamide [1247];

N-isopropyl-5-(pyrimidin-5-yl)-1H-indazole-3-carboxamide [1248];

N-(tert-butyl)-5-(5-((diethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1252];

N-(tert-butyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1253];

N-isobutyl-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1254];

5-(5-chloropyridin-3-yl)-N-isobutyl-1H-indazole-3-carboxamide [1255];

(R)—N-(sec-butyl)-5-(5-chloropyridin-3-yl)-1H-indazole-3-carboxamide [1256];

(R)—N-(sec-butyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1257];

(S)—N-(sec-butyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1258];

N-(2-(dimethylamino)ethyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1259];

N-(3-isopropoxypropyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1261];

N-(2-(piperidin-1-yl)ethyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1265];

N-(2-morpholinoethyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1267];

N-cyclopropyl-5-(pyrimidin-5-yl)-1H-indazole-3-carboxamide [1269];

N-cyclopropyl-5-(5-((diethylamino)methyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1270];

5-(5-(azetidin-1-ylmethyl)pyridin-3-yl)-N-cyclopropyl-1H-indazole-3-carboxamide [1271];

5-(5-chloropyridin-3-yl)-N-(1-isobutylazetidin-3-yl)-1H-indazole-3-carboxamide [1273];

5-(5-(difluoromethyl)pyridin-3-yl)-N-(1-isobutylazetidin-3-yl)-1H-indazole-3-carboxamide [1274];

5-(5-chloropyridin-3-yl)-N-(7-methyl-7-azaspiro[3.5]nonan-2-yl)-1H-indazole-3-carboxamide [1276];

5-(5-chloropyridin-3-yl)-N-cyclopentyl-1H-indazole-3-carboxamide [1279];

N-cyclohexyl-5-(pyrimidin-5-yl)-1H-indazole-3-carboxamide [1281];

N-(4,4-difluorocyclohexyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1283];

N-(4-aminocyclohexyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1285];

N-(4-aminocyclohexyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1286];

N-(4-(dimethylamino)cyclohexyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1287];

N-(4-(dimethylamino)cyclohexyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1288];

6-fluoro-N-(1-methylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1290];

5-(5-chloropyridin-3-yl)-N-(1-ethylpiperidin-4-yl)-1H-indazole-3-carboxamide [1291];

5-(5-chloropyridin-3-yl)-N-(1-(2-fluoroethyl)piperidin-4-yl)-1H-indazole-3-carboxamide [1296];

5-(5-chloropyridin-3-yl)-N-(1-(2,2-difluoroethyl)piperidin-4-yl)-1H-indazole-3-carboxamide [1299];

N-(1-(2,2-difluoropropyl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1300];

5-(5-chloropyridin-3-yl)-N-(1-(2,2-difluoropropyl)piperidin-4-yl)-1H-indazole-3-carboxamide [1302];

5-(5-(difluoromethyl)pyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [1303];

6-chloro-N-(1-isopropylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1304];

5-(5-chloropyridin-3-yl)-N-(1-isopropylpiperidin-4-yl)-1H-indazole-3-carboxamide [1305];

5-(5-chloropyridin-3-yl)-N-(1-isobutylpiperidin-4-yl)-1H-indazole-3-carboxamide [1307];

6-fluoro-N-(1-isobutylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1308];

N-(1-(2-fluoro-2-methylpropyl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1309];

5-(5-chloropyridin-3-yl)-N-(1-(2-fluoro-2-methylpropyl)piperidin-4-yl)-1H-indazole-3-carboxamide [1311];

5-(5-chloropyridin-3-yl)-N-(1-(cyclopropylmethyl)piperidin-4-yl)-1H-indazole-3-carboxamide [1313];

N-(1-(cyclobutylmethyl)piperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1314];

N-(1-isopentylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1316];

N-(1-(2-fluoro-2-methylpropyl)piperidin-4-yl)-5-(pyrazin-2-yl)-1H-indazole-3-carboxamide [1319];

N-(1-methylpiperidin-4-yl)-5-(4-(trifluoromethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1340];

6-fluoro-N-(1-neopentylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1342];

6-fluoro-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-N-(pyridin-2-yl)-1H-indazole-3-carboxamide [1343];

N-((3S,4R)-3-fluoro-1-isobutylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1346];

N-((3S,4S)-3-fluoro-1-isobutylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1347];

N-((3R,4R)-3-fluoro-1-isobutylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1348];

N-((3R,4S)-3-fluoro-1-isobutylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1349];

N-(6-(methylcarbamoyl)pyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1359];

N-(1-isobutyl-2-methylpiperidin-4-yl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1363];

5-(pyridin-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-1H-indazole-3-carboxamide [1366];

5-(pyridin-3-yl)-N-((tetrahydrofuran-3-yl)methyl)-1H-indazole-3-carboxamide [1369];

N-((1-(2-fluoro-2-methylpropyl)pyrrolidin-3-yl)methyl)-5-(pyridin-3-yl)-1H-indazole-3-carboxamide [1372]; and

6-fluoro-N-(6-(methylcarbamoyl)pyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide [1376]; or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

16. A pharmaceutical composition comprising a compound according to claim 14 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

Assignments (4)

RELEASE OF SECURITY INTEREST Recorded Mar 12, 2026

From: TMF GROUP NEW YORK, LLC, NOT INDIVIDUALLY BUT SOLELY AS COLLATERAL AGENT

To: BIOSPLICE THERAPEUTICS, INC.

Reel/Frame 075109/0434 →

SECURITY INTEREST Recorded Sep 14, 2022

From: BIOSPLICE THERAPEUTICS, INC.

To: VICKERS VENTURE FUND VI PTE. LTD.; VICKERS VENTURE FUND VI (PLAN) PTE. LTD.; VICKERS-SPLICE CO-INVESTMENT LLC; MED-PATHWAYS II LIMITED

Reel/Frame 061433/0786 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2021

From: SAMUMED, LLC

To: BIOSPLICE THERAPEUTICS, INC.

Reel/Frame 055693/0809 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 20, 2017

From: HOOD, JOHN; KUMAR KC, SUNIL; WALLACE, DAVID MARK; MITTAPALLI, GOPI KUMAR; HOFILENA, BRIAN JOSEPH; MAK, CHI CHING; BOLLU, VENKATAIAH; EASTMAN, BRIAN

To: SAMUMED, LLC

Reel/Frame 043052/0335 →

Continuity (3)

Division 14664517 · Mar 20, 2015

Provisional Application 61968350 · Mar 20, 2014

Related Publication 20180127377A1 · May 10, 2018