CURCUMIN-BASED PHARMACEUTICAL COMPOSITIONS AND METHODS FOR FABRICATING THEREOF
Pharmaceutical compositions are described, the compositions consisting essentially of aqueous emulsions of a therapeutically effective quantity of a diarylheptanoid compound (such as curcumin). Methods for fabricating the compositions and using them are also described.
1 . A pharmaceutical composition formulated as a colloidal emulsion that consists of:
(a) a dispersed phase consisting of particles consisting of a therapeutically effective quantity of at least one diarylheptanoid compound, or derivatives or analogs thereof; and
(b) a dispersion medium consisting of:
(b 1) at least one vegetable oil;
(b2) at least one pharmaceutically acceptable solubilizing and suspending agent selected from the group consisting of non-ionic polyoxyethlene-polyoxypropylene block copolymers;
(b3) optionally at least one additional solubilizing and suspending agent; and
(b4) a pharmaceutically acceptable carrier,
wherein the dispersed phase is dispersed within the dispersion medium.
2 . The pharmaceutical composition of claim 1 , wherein the additional solubilizing and suspending agent is present in the dispersion medium, the additional solubilizing and suspending agent being selected from the group consisting of a water-soluble derivative of cellulose, optionally partially cross-linked polyacrylates, polyoxyethylene sorbitan monolaurates, polyoxyethylene sorbitan monopalmitates, polyoxyethylene sorbitan monostearates, polyoxyethylene sorbitan monooleates, cyclodextrin and derivatives thereof.
3 . The pharmaceutical composition of claim 1 , wherein the diarylheptanoid compound is a linear diarylheptanoid.
4 . The pharmaceutical composition of claim 3 , wherein the linear diarylheptanoid is selected from the group consisting of curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, and combinations thereof.
5 . The pharmaceutical composition of claim 3 , wherein the linear diarylheptanoid has the chemical structure A:
6 . The pharmaceutical composition of claim 4 , wherein the linear diarylheptanoid is curcumin.
7 . The pharmaceutical composition of claim 2 , wherein the water-soluble derivative of cellulose is selected from the group consisting of carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, and hydroxypropyl cellulose.
8 . The pharmaceutical composition of claim 2 , wherein the second solubilizing and suspending agent is polyoxyethylene (20) sorbitan monooleate.
9 . The pharmaceutical composition of claim 2 , wherein the second solubilizing and suspending agent is hydroxypropyl β-cyclodextrin.
10 . The pharmaceutical composition of claim 1 , wherein the mass concentration of curcumin in the composition is between about 1.0% and about 2.0%.
11 . The pharmaceutical composition of claim 1 , wherein the vegetable oil is selected from the group consisting of castor oil, soybean oil, coconut oil, avocado oil, olive oil, and almond oil.
12 . The pharmaceutical composition of claim 1 , wherein the vegetable oil is a PEGylated castor oil.
13 . The pharmaceutical composition of claim 1 , wherein the non-ionic polyoxyethlene-polyoxypropylene block copolymer is poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).
14 . A method for treating, preventing or alleviating a disease, condition, syndrome, symptom, pathology, or malady in a mammalian subject in need of such treatment comprising delivery to the subject the composition of claim 1 .
15 . The method of claim 14 , wherein the disease being treated is neoplasia.
16 . A method for fabricating a pharmaceutical composition of claim 1 , the method comprising:
(a) combining at least one vegetable oil, at least one non-ionic polyoxyethlene-polyoxypropylene block copolymer, and optionally at least one additional solubilizing and suspending agent to form a first mixture, followed by
(b) while stirring, heating the first mixture to a temperature between about 50° C. and about 70° C. for about 20 to 30 minutes, followed by
(c) adding to the first mixture a therapeutically effective quantity of a diarylheptanoid compound, or derivatives or analogs thereof to form a second mixture, followed by
(d) maintaining the second mixture at a temperature between about 50° C. and about 70° C. for about 30 minutes, while stirring, followed by
(e) adding a pharmaceutically acceptable carrier while stirring for about 30 minutes, while maintaining the second mixture at a temperature between about 50° C. and about 70° C. to form a third mixture, followed by
(f) subjecting the third mixture to a shear force in a homogenizer for about 30 minutes,
to obtain the pharmaceutical composition thereby.
17 . The method of claim 16 , wherein the diarylheptanoid compound is a linear diarylheptanoid selected from the group consisting of curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, and combinations thereof.
18 . The method of claim 16 , wherein the linear diarylheptanoid is curcumin.
19 . The method of claim 16 , wherein the vegetable oil is selected from the group consisting of castor oil, soybean oil, coconut oil, avocado oil, olive oil, and almond oil.
20 . The method of claim 19 , wherein the vegetable oil is a PEGylated castor oil.
21 . The method of claim 16 , wherein the non-ionic polyoxyethlene-polyoxypropylene block copolymer is poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol).