Composition, apparatus, kit and method and uses thereof
A curable composition for use in wound care comprising, apportioned between at least one Part A and at least one Part B: one or more alkenyl-group containing polymers (i) having at least one alkenyl group or moiety per molecule, one or more SiH-containing polymers (ii) having at least one Si—H unit per molecule; and a catalyst (iii) for curing by addition of alkenyl-containing polymer (i) to SiH-containing polymer (ii), Part A and Part B independently having viscosity at 23° C. in the range 5-300 Pa·s, preferably 10-100 Pa·s, at a shearing rate of 10 s −1 , and when combined in one Part having cure time at 23° C. in the range from 0.5 min to 25 min, wherein when dispensed into a location about a wound dressing, said wound dressing overlying a wound site and skin thereabout, said dispensing being so as to intimately contact and overlie an edge of said dressing and skin about said edge, the composition cures in contact with said edge and skin at 32° C. to an elastomer exhibiting zero or low tack at a time in the range from 0.5 to less than 30 minutes, apparatus for use with said composition comprising dispensing apparatus or wound dressing, a kit comprising the same, and methods of dispensing and curing the same and of using the same in sealing a wound dressing and in treating a wound site of a human in need thereof.
1. A method of treating a wound site, comprising:
applying a wound dressing having a substantially fluid-tight drape to the wound site, wherein the dressing comprises an outer perimeter adapted to be placed in contact with skin surrounding the wound site;
applying negative pressure to the wound site through or under the drape using a source of negative pressure;
monitoring negative pressure at the wound site compared to negative pressure generated at the source of negative pressure or at a port of the wound dressing;
identifying a leak between the wound dressing and the skin about the dressing;
dispensing a sealant composition to at least a portion of the outer perimeter of the wound dressing where the leak occurs, wherein the sealant composition is dispensed to the wound dressing positioned over the wound site such that the sealant composition at least partially overlies the wound dressing at an edge of the wound dressing to form an exposed seal at the edge, wherein the sealant composition cures in contact with both the wound dressing and the skin, wherein the sealant composition is apportioned between at least one Part A and at least one Part B and comprises:
one or more alkenyl-group containing polymers having at least one alkenyl group or moiety per molecule;
one or more SiH-containing polymers having at least one Si—H unit per molecule; and
a catalyst for curing by addition of the one or more alkenyl-group containing polymers to the one or more SiH-containing polymers;
wherein dispensing the sealant composition comprises combining Part A and Part B; and
curing a combination of Parts A and B to form a seal at the portion of the outer perimeter of the wound dressing where the leak occurs after the wound dressing is positioned over the wound site, wherein the combination of Parts A and B cures in a time between approximately 0.5 min to approximately 25 min and the composition cures to an elastomer exhibiting zero or low tack at a time ranging from approximately 0.5 minutes to approximately 30 minutes.
2. The method of claim 1 , wherein the seal is exposed at the edge and provides an air-tight seal between the wound dressing and the skin about the dressing.
3. The method of claim 1 , wherein the outer perimeter of the wound dressing comprises a skin-contacting face and an upper face configured to be positioned facing away from the skin, wherein the sealant composition cures in contact with and overlying the upper face of the wound dressing.
4. The method of claim 1 , further comprising drawing the sealant composition between the wound dressing and the skin at the location of the leak.
5. The method of claim 1 , further comprising dispensing the sealant composition in the form of a bead or film at discrete points, thereby bridging an interface between the wound dressing and the skin.
6. The method of claim 1 , further comprising placing a wound packing material within the wound site and applying the wound dressing to the wound site with the wound dressing covering the wound packing material.
7. The method of claim 1 , wherein applying the wound dressing comprises adhering the wound dressing over the wound site with an adhesive disposed on an underside of the wound dressing.
8. A method of treating a wound site, comprising:
applying a wound dressing to the wound site, wherein the wound dressing comprises an outer perimeter adapted to be placed in contact with skin surrounding the wound site; and
dispensing a sealant composition to at least a portion of the outer perimeter of the wound dressing, wherein the sealant composition is dispensed to the wound dressing positioned over the wound site such that the sealant composition at least partially overlies the wound dressing at an edge of the wound dressing to form an exposed seal at the edge, wherein the sealant composition cures in contact with both the wound dressing at the outer perimeter and the skin at the outer perimeter, wherein the sealant composition is apportioned between at least one Part A and at least one Part B and comprises:
one or more alkenyl-group containing polymers having at least one alkenyl group or moiety per molecule;
one or more SiH-containing polymers having at least one Si—H unit per molecule; and
a catalyst for curing by addition of the one or more alkenyl-group containing polymers to the one or more SiH-containing polymers; and
wherein dispensing the sealant composition comprises combining Part A and Part B after the wound dressing is positioned over the wound site, wherein a combination of Parts A and B cures in a time between approximately 0.5 min to approximately 25 min and the composition cures to an elastomer exhibiting zero or low tack at a time ranging from approximately 0.5 minutes to approximately 30 minutes.
9. The method of claim 8 , wherein the sealant composition cures in contact with and overlying substantially the entire outer perimeter and skin thereabout.
10. The method of claim 8 , wherein the outer perimeter of the wound dressing comprises a skin-contacting face and an upper face to be positioned remotely from and facing away from the skin, wherein the sealant composition cures in contact with and overlying the wound dressing at the upper face thereof.
11. The method of claim 8 , further comprising applying negative pressure to the wound site through the wound dressing, wherein the cured sealant composition provides an air-tight seal between the wound dressing and the skin.
12. The method of claim 11 , further comprising:
identifying at least one location where a leak allows ingress of air between the wound dressing and the skin about the dressing after applying negative pressure; and
dispensing the sealant composition to at least the portion of the outer perimeter of the wound dressing at the location of the leak, wherein the cured sealant composition provides the air-tight seal at the location of the leak.
13. The method of claim 8 , further comprising placing a wound packing material within the wound site and applying the wound dressing to the wound site with the wound dressing covering the wound packing material.
14. The method of claim 8 , wherein the wound dressing comprises a substantially fluid-tight drape, the method further comprising applying negative pressure to the wound site through or under the drape using a source of negative pressure.
15. The method of claim 14 , wherein applying negative pressure is performed at least partially before dispensing the sealant composition.
16. The method of claim 15 , further comprising monitoring negative pressure at the wound site compared to negative pressure generated at the source of negative pressure.
17. The method of claim 16 , further comprising:
identifying a location where a leak allows ingress of air between the wound dressing and the skin about the dressing; and
dispensing the sealant composition to at least the portion of the outer perimeter of the wound dressing at the location of the leak.
18. The method of claim 17 , further comprising drawing the sealant composition between the wound dressing and the skin at the location of the leak using the negative pressure.
19. The method of claim 8 , wherein applying the wound dressing comprises adhering the wound dressing over the wound site with an adhesive disposed on an underside of the wound dressing.