Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions
A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
1. A method for characterizing a Type I diabetes condition for a subject, the method comprising:
for each sample of an aggregate set of samples comprising at least one sample comprising microorganisms associated with the Type I diabetes condition:
determining a microorganism nucleic acid sequence upon amplifying nucleic acid material of the sample using a primer; and
determining an alignment of the microorganism nucleic acid sequence to a reference nucleic acid sequence;
generating a microbiome feature dataset, including diversity features associated with at least one of microbiome composition features and microbiome functional features, based on the alignments;
generating a characterization of the Type I diabetes condition based on the microbiome feature dataset;
determining a therapy for the subject based on the characterization and a subject sample from the subject; and
providing the therapy to the subject, wherein the therapy is operable to modulate microbiome composition to improve a state of the Type I diabetes condition.
2. The method of claim 1 , further comprising: determining, with a primer design model, the primer for the microorganism nucleic acid sequence associated with the Type I diabetes condition.
3. The method of claim 2 , wherein determining the primer comprises identifying the primer corresponding to a 16S RNA sequence associated with a set of taxa.
4. The method of claim 1 , wherein generating the characterization omits assessment of hyperglycemic conditions in the subject.
5. The method of claim 1 , wherein generating the characterization comprises generating the characterization based on a set of microbiome composition features for a set of taxa associated with at least one of: relative abundance features, presence features, and absence features, and ratio between at least two features comprising taxonomic groups and functional features, interactions between different taxonomic groups, and phylogenetic distance between the different taxonomic groups or any combination of microbiome composition features.
6. The method of claim 5 , wherein generating the characterization of the Type I diabetes condition comprises evaluating features of the microbiome feature dataset associated with a first taxonomic feature associated with Porphyromonadaceae (family).
7. The method of claim 6 , wherein generating the characterization of the Type I diabetes condition comprises evaluating features of the microbiome feature dataset associated with a second taxonomic feature associated with Oscillibacter (genus).
8. The method of claim 7 , wherein generating the characterization of the Type I diabetes condition comprises evaluating features of the microbiome feature dataset associated with a third taxonomic feature associated with Peptococcus (genus).
9. The method of claim 8 , wherein generating the characterization of the Type I diabetes condition comprises evaluating features of the microbiome feature dataset associated with taxonomic features associated with at least one of: Peptoniphilus (genus), Ruminococcus faecis (species), and Oceanospirillales (order).
10. The method of claim 8 , wherein generating the characterization of the Type I diabetes condition comprises evaluating features of the microbiome feature dataset associated with a set of functional features derived from at least one of: clusters of orthologous groups of proteins features, genomic functional features from the Kyoto Encyclopedia of Genes and Genomes (KEGG), chemical functional features, and systemic functional features.
11. The method of claim 1 , wherein generating the characterization further comprises extracting a supplementary dataset from a population of subjects associated with the aggregate set of samples, the supplementary dataset comprising data from a fasting glucose level test assessing at least one of plasma, blood and interstitial glucose levels.
12. A method for at least one of characterizing and treating a Type I diabetes condition in a subject, the method comprising:
receiving a sample from the subject;
determining a microorganism sequence for content of the sample upon amplifying nucleic acid material of the sample using a primer;
generating a microbiome feature dataset from the microorganism sequence;
generating a characterization of the Type I diabetes condition in the subject upon processing the microbiome feature dataset with a characterization model associated with a set of subjects; and
providing a therapy to the subject based on the characterization, wherein the therapy is operable to improve a state of the Type I diabetes condition.
13. The method of claim 12 , wherein generating the characterization comprises evaluating features of the microbiome feature dataset associated with at least one of: Porphyromonadaceae (family), Oscillibacter (genus), and Peptococcus (genus).
14. The method of claim 13 , wherein generating the characterization comprises evaluating features of the microbiome feature dataset further associated with at least one of: Peptoniphilus (genus), Ruminococcus faecis (species), and Oceanospirillales (order).
15. The method of claim 12 , wherein determining the microorganism sequence comprises implementing a primer selection model to identify the primer, and wherein the primer includes a unique barcode sequence.
16. The method of claim 15 , wherein determining the microorganism sequence comprises amplifying with at least one of a bridge amplification substrate and moiety-bound particles of a next generation sequencing platform.
17. The method of claim 12 , wherein providing the therapy comprises providing instructions to the subject regarding setup of a user account with a patient portal configured to provide microbiome-derived insights to the subject, and transmitting diagnostic information and behavioral therapeutic techniques, associated with correcting the Type I diabetes condition, through a social networking system.
18. The method of claim 17 , wherein providing the therapy comprises providing a consumable to the subject, the consumable operable to modulate microbiome function towards an equilibrium condition to improve the state of the Type I diabetes condition.
19. The method of claim 18 , wherein providing the therapy comprises analyzing a set of probiotic compositions, and selecting at least one of the set of probiotic compositions to automatically deliver to the subject.
20. The method of claim 19 , wherein providing the therapy further comprises delivering information pertaining to the at least one of the set of probiotic compositions, to the subject through the patient portal.