Compositions for oral drug administration
View Patent ↗The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms. In various aspects, the invention provides compositions and methods for oral delivery in the form of a tablet.
1. A method of increasing the bioavailability of an active ingredient in a subject comprising orally administering an absorption increasing amount of an alkylglycoside with the active ingredient, in solid dosage form, wherein the active ingredient is phenylephrine and the alkylsaccharide is dodecyl-beta-D-maltoside, thereby increasing the bioavailability of the active ingredient in the subject.
2. The method of claim 1 , wherein the solid dosage form is a tablet.
3. The method of claim 1 , wherein C max is 2, 3, 4, 5, 6, 7, 8 or 9-fold greater as compared to delivery without alkylglycoside.
4. The method of claim 1 , wherein the alkylglycoside concentration is between about 0.05% and 10% (w/v).