Beta-klotho binding proteins
The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
1. An antibody or binding fragment thereof that binds human beta klotho, which comprises: (a) a heavy chain CDR1 comprising SEQ ID NO:1, a heavy chain CDR2 comprising SEQ ID NO:22, a heavy chain CDR3 comprising SEQ ID NO:3; and (b) a light chain CDR1 comprising SEQ ID NO:4, a light chain CDR2 comprising SEQ ID NO:5, and a light chain CDR3 comprising SEQ ID NO:6.
2. The antibody of claim 1 , which comprises a heavy chain variable region having at least 90% sequence identity to SEQ ID NO:25 and a light chain variable region having at least 90% sequence identity to SEQ ID NO:26.
3. The antibody of claim 2 , which comprises a heavy chain variable region comprising SEQ ID NO:25 and a light chain variable region comprising SEQ ID NO:26.
4. The antibody of claim 1 , which comprises a heavy chain variable region having at least 90% sequence identity to SEQ ID NO:271 and a light chain variable region having at least 90% sequence identity to SEQ ID NO:276.
5. The antibody of claim 4 , which comprises a heavy chain variable region comprising SEQ ID NO:271 and a light chain variable region comprising SEQ ID NO:276.
6. A pharmaceutical composition which comprises the antibody of claim 5 and a pharmaceutically acceptable carrier.
7. The antibody of claim 1 , which is a monoclonal antibody.
8. The antibody of claim 1 , which is a humanized antibody.
9. A pharmaceutical composition which comprises the antibody of claim 1 and a pharmaceutically acceptable carrier.
10. The antibody of claim 1 , which is an IgG1 antibody.
11. The antibody of claim 1 , which is an IgG2 antibody.
12. The antibody of claim 1 , which is an IgG4 antibody.
13. The antibody of claim 1 , which is a bispecific antibody.
14. An antibody that binds human beta klotho, which comprises a heavy chain comprising amino acids 23-472 of SEQ ID NO:317 and a light chain comprising amino acids 23-240 of SEQ ID NO:319.
15. A pharmaceutical composition which comprises the antibody of claim 14 and a pharmaceutically acceptable carrier.