IP Library › Granted Patent US 10,844,107
Granted Patent B2
US 10,844,107 · App. 15/659,612 · Granted Nov 24, 2020

HIV VPR-specific T-cell receptors

Inventors: Marilyn Fernandez (Surfside, FL); Bai Liu (Cooper City, FL); Warren Marcus (Miramar, FL); Hing C. Wong (Weston, FL)
Assignee: ALTOR BIOSCIENCE, LLC
C07K14/70503C07K14/705C07K14/7051G01N33/56988
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Quick Facts
Patent No.
US 10,844,107
App. No.
15/659,612
Granted
Nov 24, 2020
Kind
B2
Abstract

The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQQL).

Claims (6)

1. A method of killing a cell infected with human immunodeficiency virus type 1 (HIV-1), the method comprising: contacting the cell with an isolated T cell receptor (TCR) wherein the isolated TCR has an amino acid sequence according to SEQ ID No. 3, and wherein the HIV-1 expresses an AL9 Vpr peptide.

2. A method for inhibiting replication of human immunodeficiency virus type 1 (HIV-1), the method comprising: administering from 10 μg/kg to 150 λg/kg of an isolated T cell receptor (TCR) wherein the isolated TCR has an amino acid sequence according to SEQ ID No. 3, and wherein the HIV-1 expresses an AL9 Vpr peptide.

3. The method of claim 1 wherein the TCR is a single-chain TCR.

4. The method of claim 1 wherein the TCR is a heterodimeric TCR.

5. The method of claim 2 wherein the TCR is a single-chain TCR.

6. The method of claim 2 wherein the TCR is a heterodimeric TCR.

Assignments (3)
SECURITY INTEREST Recorded Jan 2, 2024
From: IMMUNITYBIO, INC.; NANTCELL, INC.; RECEPTOME, INC.; VBC HOLDINGS LLC; ALTOR BIOSCIENCE, LLC; ETUBICS CORPORATION; IGDRASOL, INC.
To: INFINITY SA LLC, AS PURCHASER AGENT
Reel/Frame 066179/0074 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 23, 2022
From: FERNANDEZ, MARILYN; LIU, BAI; MARCUS, WARREN D.; WONG, HING C.
To: ALTOR BIOSCIENCE CORPORATION
Reel/Frame 061199/0635 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 14, 2018
From: ALTOR BIOSCIENCE CORPORATION
To: ALTOR BIOSCIENCE, LLC
Reel/Frame 047498/0770 →
Continuity (4)
Continuation 14560314 · Dec 4, 2014
Division 12731485 · Mar 25, 2010
Provisional Application 61163421 · Mar 25, 2009
Related Publication 20180148493A1 · May 31, 2018