Donepezil transdermal delivery system
View Patent ↗A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.
1. A composition, comprising:
a drug reservoir comprising (i) donepezil base generated in situ in the drug reservoir by reaction of donepezil HCl and a pharmaceutically acceptable alkaline salt selected from sodium bicarbonate and potassium bicarbonate, said donepezil HCl and said alkaline salt present in the drug reservoir in an equimolar or less than equimolar ratio of alkaline salt to donepezil HCl; (ii) glycerine; and (iii) an acrylate copolymer, wherein the donepezil base is generated for a period of between about 3-10 days in an amount that provides a therapeutically effective dose of donepezil base to a human for the period.
2. The composition of claim 1 , wherein the drug reservoir further comprises triethyl citrate or sorbitan monolaurate.
3. The composition of claim 1 , wherein the drug reservoir comprises an acrylic acid/vinyl acetate copolymer adhesive and a crosslinked polyvinylpyrrolidone.
4. A composition, comprising:
a drug reservoir consisting essentially of donepezil base generated in situ in the drug reservoir by reaction of a molar amount of donepezil HCl and an equimolar or less than equimolar amount of sodium bicarbonate; a solvent composition comprising one or more of triethyl citrate, lauryl lactate, sorbitan monolaurate, and glycerin; crosslinked polyvinylpyrrolidone and an acrylate copolymer, wherein donepezil base is generated for a period of between about 3-10 days in an amount that provides a therapeutically effective dose of donepezil base to a human for the period.
5. A composition, comprising:
a drug reservoir consisting essentially of:
(a) donepezil base generated in situ for a period of between about 3-10 days in the drug reservoir by reaction of between about 5-25 wt % donepezil HCl and between about 1-5 wt % sodium bicarbonate, said donepezil HCl and said sodium bicarbonate present in the drug reservoir in an equimolar or less than equimolar ratio of sodium bicarbonate to donepezil HCl;
(b) about 0-15 wt % triethyl citrate;
(c) about 0-5 wt % sorbitan monolaurate
(d) about 5-15 wt % glycerin;
(e) about 1-10 wt % lauryl lactate;
(f) about 5-25 wt % crosslinked polyvinylpyrrolidone; and
(g) about 30-65 wt % acrylate-vinylacetate copolymer.
6. A composition, comprising:
a drug reservoir consisting essentially of:
(a) donepezil base generated in situ for a period of between about 3-10 days in the drug reservoir by reaction of between about 10-18 wt % donepezil HCl and an equimolar or less than equimolar amount of sodium bicarbonate, wherein the weight percent of sodium bicarbonate in the drug reservoir is between about 1-5 wt %;
(b) about 8-12 wt % triethyl citrate;
(c) about 1.5-2.5 wt % sorbitan monolaurate
(d) about 9-11 wt % glycerin;
(e) about 1-10 wt % lauryl lactate;
(f) about 13-17 wt % crosslinked polyvinylpyrrolidone; and
(g) about 40-42 wt % acrylate-vinylacetate copolymer.
7. The composition of claim 1 , further comprising a contact adhesive layer.
8. The composition of claim 7 , further comprising an intermediate layer positioned between the contact adhesive layer and the drug reservoir.
9. The composition of claim 1 , wherein the amount of donepezil base generated is an amount that yields a plasma concentration bioequivalent to oral administration of donepezil hydrochloride at a daily dose selected from 5 mg, 10 mg, and 23 mg.
10. The composition of claim 1 , wherein the amount of donepezil base generated is an amount that yields at approximately steady state a transdermal plasma concentration bioequivalent to oral administration of donepezil hydrochloride at a daily dose selected from 5 mg, 10 mg, and 23 mg.
11. The composition of claim 1 , wherein the amount of donepezil base is generated continuously over the period to provide a therapeutically effective dose of between about 1-25 mg/day.
12. The composition of claim 1 , wherein greater than about 10 wt % donepezil HC is present in the drug reservoir and an equimolar or less than equimolar amount of the pharmaceutically acceptable alkaline salt, wherein the weight percent of alkaline salt in the drug reservoir is between about 2-5 wt %.
13. The composition of claim 1 , wherein greater than about 14 wt % donepezil HC is present in the drug reservoir and the pharmaceutically acceptable alkaline salt is present at about 2.6 wt % or less.
14. The composition of claim 1 , wherein donepezil HCl and the pharmaceutically acceptable alkaline salt are present in the drug reservoir in an equimolar amount or at a molar ratio of 0.82.