Automated drug delivery systems and methods
Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.
1. A drug delivery system, comprising:
a controller;
a drug delivery device;
an actuator in fluid communication with the drug delivery device, the actuator including a fluid reservoir having a drug disposed therein;
an actuation line connecting the actuator to the controller, the actuation line being configured to transmit from the controller to the actuator: (i) a first actuation force to urge fluid out of the drug delivery device, and (ii) a second actuation force to draw fluid into the drug delivery device; and
a user control mounted to the actuator and selectively operable to transmit a signal to the controller.
2. The system of claim 1 , wherein the drug delivery device comprises a needle.
3. The system of claim 1 , wherein the actuation line does not include a drug.
4. The system of claim 1 , wherein the controller is remote from the actuator, such that the controller is configured to be disposed outside of a sterile field while the actuator is disposed within the sterile field.
5. The system of claim 1 , further comprising a signal line configured to transmit information between the controller and the actuator.
6. The system of claim 5 , wherein the drug delivery device includes a sensor communicably coupled to the controller via the signal line.
7. The system of claim 6 , wherein the sensor comprises a pressure sensor.
8. The system of claim 7 , wherein the controller is configured to:
receive data from the pressure sensor; and
stop operation of the actuator in response to determining that the data from the pressure sensor indicates a pressure greater than a threshold pressure.
9. The system of claim 1 , wherein the fluid reservoir comprises a syringe and wherein the first actuation force is effective to move a plunger of the syringe distally and the second actuation force is effective to move the plunger proximally.
10. The system of claim 1 , further comprising one or more sensors operably coupled to the controller, the one or more sensors comprising one or more of:
electrocardiogram sensors; heart rate sensors; temperature sensors; PH sensors, respiration rate sensors; respiration volume sensors; lung capacity sensors; chest expansion and contraction sensors; or pressure sensors.
11. The system of claim 10 , wherein the controller is configured to:
receive signals from the one or more sensors; and
process the signals to at least one of: detect a frequency; detect a phase; debounce one of the signals; convert one of the signals from analog to digital; or filter one of the signals.
12. The system of claim 1 , wherein the controller comprises:
a processor; and
a memory having instructions stored thereon that cause the processor to perform operations, the operations comprising at least one of: select one of a plurality of infusion types; select an infusion rate; select an infusion volume; select a time between infusions; select an oscillatory rate; select an infusion and withdraw ratio; select an infusion phase timing; select an aspiration type; select an aspiration rate; select a time between aspirations; select an aspiration volume.
13. The system of claim 1 , wherein the actuator comprises a plurality of fluid reservoirs.
14. The system of claim 13 , wherein the actuation line comprises a plurality of actuation lines connecting individual ones of the plurality of fluid reservoirs to the controller.
15. The system of claim 1 , further comprising a display configured to display information to a user.
16. The system of claim 1 , further comprising a user input configured to receive input from a user, the input comprising at least one of: infusion parameters; patient information; or treatment protocols.
17. The system of claim 1 , wherein the actuator further comprises a valve operable to control flow of fluid from the actuator; and the actuation line being configured to transmit from the controller to the actuator the first actuation force comprises the actuation line being configured to transmit from the controller to the actuator a signal to open the valve.
18. The system of claim 1 , wherein the first and second actuation forces are transmitted pneumatically, hydraulically, mechanically, or electrically.
19. The system of claim 1 , wherein the drug delivery device comprises a catheter.
20. A drug delivery system, comprising:
a controller;
a drug delivery device;
an actuator in fluid communication with the drug delivery device, the actuator including a fluid reservoir having a drug disposed therein;
an actuation line connecting the actuator to the controller, the actuation line being configured to transmit from the controller to the actuator at least one of (i) a first actuation force to urge fluid out of the drug delivery device, and (ii) a second actuation force to draw fluid into the drug delivery device,
wherein the actuation line comprises a flexible cable disposed within an outer sheath, the cable being at least one of axially translatable and axially rotatable relative to the outer sheath to provide the at least one of (i) the first actuation force to urge fluid out of the drug delivery device, and (ii) the second actuation force to draw fluid into the drug delivery device.