Absorbable polymer with drug elution for a magnet sphincter assist device
An apparatus is configured to be implanted within a biological structure. The apparatus includes a plurality of magnetic elements, an absorbable component, and a non-absorbable component. The plurality of magnetic elements are configured to transition the biological structure between an occluded state and an opened state. The plurality of magnetic elements are biased to encourage the biological structure toward the occluded state. The absorbable component includes a therapeutic substance. The absorbable component is configured to temporarily couple the plurality of magnetic elements with the biological structure when the apparatus is initially implanted within the biological structure.
1. An apparatus configured to be implanted within a biological structure, the apparatus comprising:
(a) a plurality of magnetic elements configured to transition the biological structure between an occluded state and an opened state, wherein the plurality of magnetic elements are biased to encourage the biological structure toward the occluded state;
(b) an absorbable component comprising a therapeutic substance, wherein the absorbable component is configured to at least temporarily couple the plurality of magnetic elements with the biological structure when the apparatus is initially implanted within the biological structure such that the absorbable component initially supports the plurality of magnetic elements relative to the biological structure; and
(c) a non-absorbable component.
2. The apparatus of claim 1 , wherein the therapeutic substance comprises an anti-inflammatory agent.
3. The apparatus of claim 1 , wherein the therapeutic substance comprises an MMP inhibitor.
4. The apparatus of claim 1 , wherein the absorbable component comprises a plurality of column-like vertical structures configured to promote tissue in-growth.
5. The apparatus of claim 4 , wherein the column-like vertical structures are resilient.
6. The apparatus of claim 1 , wherein the non-absorbable component comprises a coiled suture, wherein the coiled suture couples the plurality of magnets and the absorbable component.
7. The apparatus of 1 , wherein the therapeutic substance comprises an antibiotic.
8. The apparatus of claim 1 , wherein the therapeutic substance comprises an antimicrobial agent.
9. The apparatus of claim 1 , wherein the absorbable component defines a hollow area, wherein the therapeutic substance is located within the hollow area.
10. The apparatus of claim 8 , wherein the therapeutic substance is configured to elute from the absorbable component as the absorbable component absorbs.
11. The apparatus of claim 1 , wherein the therapeutic substance comprises an agent configured to heal tissue.
12. The apparatus of claim 1 , wherein the therapeutic substance comprises an agent configured to physically protect tissue from an acidic compound.
13. The apparatus of claim 1 , wherein the therapeutic substance comprises a steroid.
14. The apparatus of claim 1 , wherein the therapeutic substance comprises a growth factor.
15. The apparatus of claim 1 , wherein the therapeutic substance comprises an antifungal agent.
16. The apparatus of claim 1 , wherein therapeutic substance comprises a drug.
17. An apparatus configured to be implanted within a biological structure, the apparatus comprising:
(a) a plurality of magnetic elements configured to transition the biological structure between an occluded state and an opened state, wherein the plurality of magnetic elements are biased to encourage the biological structure toward the occluded state, wherein the plurality of magnetic elements are disposed about a central axis;
(b) an absorbable component comprising a therapeutic substance, wherein the plurality of magnetic elements are disposed between the absorbable component and the central axis, wherein the therapeutic substance is configured to at least temporarily support the plurality of magnetic elements relative to the biological structure when the apparatus is initially implanted within the biological structure; and
(c) a non-absorbable component configured to support the plurality of magnetic elements relative to the biological structure after the absorbable component is bio-absorbed.
18. The apparatus of claim 17 , wherein the apparatus comprises a silicone bag, wherein the plurality of magnetic elements are disposed within the silicone bag.
19. An apparatus configured to be implanted within a biological structure, the apparatus comprising:
(a) a plurality of magnetic elements disposed about a central axis configured to transition the biological structure between an occluded state and an opened state, wherein the plurality of magnetic elements are biased to encourage the biological structure toward the occluded state;
(b) an absorbable component located further away from the central axis compared to the plurality of magnetic elements, wherein the absorbable component comprises a therapeutic substance, wherein the absorbable component is configured to at least temporarily couple the plurality of magnetic elements with the biological structure when the apparatus is initially implanted within the biological structure; and
(c) a non-absorbable component.
20. The apparatus of claim 19 , wherein the non-absorbable component comprises a coil disposed around the plurality of magnetic elements.