Therapeutic angiogenesis for treating erectile conditions
Disclosed are devices, methods and surgical procedures for detecting, imaging, analyzing, diagnosing and/or treating vascular disorders and related conditions of the human and mammalian body in males and/or females. In particular embodiments, treatments include methods for imaging, analyzing and improving erectile dysfunction and related conditions and potentially increasing angiogenesis in response to specifically diagnosed conditions.
1. A method of treating an erectile condition of a subject, comprising:
obtaining non-invasive image data of at least a portion of a pelvic region of the subject, the non-invasive image data including a region of pelvic vasculature,
analyzing the image data to preoperatively identify at least one ischemic region of the pelvic vasculature,
preoperatively identifying a first treatment site proximate to the ischemic region of the pelvic vasculature,
administering a therapeutically effective amount of a first composition comprising at least one angiogenic factor to the first treatment site, wherein the administration of the angiogenic factor induces growth of blood vessels and angiogenesis at a location proximate to the ischemic region of pelvic vasculature.
2. The method of claim 1 , wherein the growth of blood vessels and angiogenesis increases a flow of blood through the ischemic region of pelvic vasculature.
3. The method of claim 1 , wherein the step of administering the therapeutically effective amount of the first composition comprises topically applying the first composition to a region of skin tissue at the first treatment site.
4. The method of claim 1 , wherein the step of administering the therapeutically effective amount of the first composition comprises injecting the first composition into the first treatment site.
5. The method of claim 1 , wherein the step of administering the therapeutically effective amount of the first composition comprises introducing the first composition intravenously into the vascular system of the patient.
6. The method of claim 1 , wherein the step of analyzing the image data to preoperatively identify at least one ischemic region of the penile vasculature comprises creating a hemodynamic model of at least a portion of the pelvic blood flow.
7. The method of claim 1 , wherein the first treatment site is located upstream from the ischemic region.
8. The method of claim 1 , wherein the at least one angiogenic factor comprises FGF-1.
9. The method of claim 1 , wherein the region of pelvic vasculature includes a region of penile vasculature.
10. The method of claim 1 , wherein the region of pelvic vasculature includes a region of clitoral vasculature.
11. The method of claim 1 , wherein the hemodynamic model of at least a portion of the pelvic blood flow region of the pelvic vasculature includes a hemodynamic model of the penile vasculature of the patient.
12. The method of claim 1 , wherein the hemodynamic model of at least a portion of the pelvic blood flow region of the pelvic vasculature includes a hemodynamic model of the clitoral vasculature of the patient.
13. A method of treating an erectile condition of a subject, comprising:
obtaining non-invasive image data of at least a portion of a pelvic region of the subject, the non-invasive image data including a region of pelvic vasculature;
analyzing the image data to preoperatively identify at least one hyperperfused region of the pelvic vasculature;
preoperatively identifying a first treatment site proximate to the hyperperfused region of the pelvic vasculature; and
administering a therapeutically effective amount of a first composition comprising a constrictive agent into the first treatment site, wherein the administration of the constrictive agent reduces blood flow through the hyperperfused region of the pelvic vasculature.
14. The method of claim 13 , wherein the constrictive agent comprises a cyanoacrylate adhesive.
15. The method of claim 13 , wherein the constrictive agent comprises a vasoconstrictive agent.
16. The method of claim 13 , wherein the constrictive agent comprises pseudoephedrine.
17. The method of claim 13 , wherein the hyperperfused region of the pelvic vasculature comprises a venous blood drainage network of a penis.
18. A method for improving blood flow in a region of ischemic subsurface tissue of the pelvis:
obtaining non-invasive image data of at least a portion of a pelvic region of the subject;
analyzing the image data to preoperatively identify at least one ischemic region of pelvic vasculature within the pelvic region; and
applying to a tissue site adjacent to the ischemic region an effective amount of a compound comprising FGF-1, wherein the effective amount of the compound promotes angiogenesis within at least a portion of the ischemic region, thereby improving blood flow in the region of ischemic subsurface tissue.
19. The method of claim 18 , wherein the step of applying to the tissue site adjacent to the ischemic region an effective amount of a compound comprising FGF-1 comprises applying to a surface tissue site adjacent to the ischemic region an effective amount of a compound comprising FGF-1.
20. The method of claim 18 , wherein the step of applying to the tissue site adjacent to the ischemic region an effective amount of a compound comprising FGF-1 comprises applying to a subsurface tissue site adjacent to the ischemic region an effective amount of a compound comprising FGF-1.