Systems and method for treating eye diseases using retrograde blood flow

1. A method, comprising:

positioning a first device within an ophthalmic artery of the subject;

inducing retrograde flow in the ophthalmic artery of the subject; and

treating at least one of a blockage, a stenosis, a lesion, plaque, or other physiology in at least one of the ophthalmic artery and the junction between an internal carotid artery and the ophthalmic artery.

2. The method of claim 1 , further including positioning a second device within a venous system of the subject.

3. The method of claim 2 , wherein the first device is a first sheath, and the second device is a second sheath, and further including fluidly coupling the first sheath with the second sheath.

4. The method of claim 3 , further including regulating retrograde flow via a control assembly fluidly coupled to the first sheath and the second sheath.

5. The method of claim 2 , wherein positioning the second device within the venous system includes positioning the second device within an internal jugular vein of the subject.

6. The method of claim 1 , wherein the first device includes an expandable portion on a distal end thereof, the method further including expanding the expandable portion so as to impede antegrade blood flow in a portion of the ophthalmic artery of the subject.

7. The method of claim 6 , wherein expanding the expandable portion includes imparting a pressure gradient differential between the ophthalmic artery and a venous system of the subject.

8. The method of claim 1 , wherein the expandable portion includes a balloon, the method further including delivering an inflation fluid to the balloon.

9. The method of claim 1 , wherein the first device includes an expandable portion, the method further including contacting an arterial vessel wall via the expandable portion.

10. The method of claim 1 , further including receiving the induced retrograde flow into a distal end of the first device.

11. The method of claim 1 , further including dislodging at least a portion of the blockage, the stenosis, the lesion, or the plaque.

12. The method of claim 11 , further including conveying the dislodged portion upstream of the ophthalmic artery via the induced retrograde flow.

13. The method of claim 1 , further including filtering the induced retrograde flow.

14. The method of claim 1 , further comprising extending a second device through a lumen of the first device.

15. A method, comprising:

expanding at least a portion of a first device positioned within an arterial system of a subject and inducing retrograde blood flow through an ophthalmic artery of the subject; and

dislodging at least a portion of a blockage, a stenosis, a lesion, or plaque of at least one of the ophthalmic artery and a junction between an internal carotid artery and the ophthalmic artery.

16. The method of claim 15 , wherein expanding the at least a portion of the first device includes imparting a pressure gradient differential between the arterial system and a venous system of the subject.

17. The method of claim 16 , further including fluidly coupling the first device with a second device positioned within the venous system of the subject.

18. The method of claim 15 , further including conveying the dislodged portion upstream of the ophthalmic artery via the induced retrograde blood flow.

19. The method of claim 15 , further including receiving the induced retrograde blood flow into a distal end of the first device.

20. The method of claim 15 , further including regulating the induced retrograde blood flow via a control assembly fluidly coupled to the first device.

21. A method, comprising:

fluidly coupling a first device located within an arterial system of a subject with a second device located within a venous system of the subject;

inducing a flow of blood from an ophthalmic artery of the subject, through the first device, through the second device, and into the venous system of the subject; and

treating at least one of the ophthalmic artery and a junction between an internal carotid artery and the ophthalmic artery of the subject.

22. The method of claim 21 , wherein the first device includes an expandable portion on a distal end thereof, the method further including expanding the expandable portion to impede antegrade blood flow in at least a portion of the arterial system of the subject.

23. The method of claim 22 , wherein the expandable portion includes a balloon, the method further including delivering an inflation fluid to the balloon.

24. The method of claim 21 , further including regulating the flow of blood via a control assembly fluidly coupled to the first device and the second device.

25. The method of claim 21 , further including conveying tissue, debris, or material of a blockage, a stenosis, or a lesion upstream of the ophthalmic artery via the induced flow of blood.

26. The method of claim 21 , further including positioning the first device within at least one of the ophthalmic artery or the internal carotid artery of the subject.

27. The method of claim 21 , further including positioning the second device within an internal jugular vein of the subject.

28. A method, comprising:

inducing retrograde flow within an ophthalmic artery of a subject via a first device located within an arterial system of the subject;

extending a second device through a lumen of the first device; and

treating the ophthalmic artery.

29. The method of claim 28 , wherein the first device is a first sheath, the method further including fluidly coupling the first sheath with a second sheath positioned within the venous system of the subject.

30. The method of claim 28 , wherein the first device includes an expandable portion on a distal end thereof, the method further including expanding the expandable portion so as to impede antegrade blood flow in at least a portion of the arterial system of the subject.