Flibanserin for the treatment of urinary incontinence and related diseases
View Patent ↗The invention relates to the use of Flibanserin for the treatment or prevention of urinary incontinence and related diseases. In a further embodiment, the instant invention is directed to pharmaceutical combinations comprising flibanserin as one active ingredient in combination with at least one additional active ingredient for the treatment or prevention of urinary incontinence and related diseases.
1. A method for treating or preventing urinary incontinence comprising administering a therapeutically effective amount of Flibanserin 1, or a pharmacologically acceptable acid addition salt hydrate, or solvate thereof.
2. The method for treating or preventing urinary incontinence according to claim 1 , further comprising administering and an active ingredient 2, or a pharmaceutically acceptable salts, hydrate, or solvate thereof.
3. The method for treating or preventing urinary incontinence according to claim 1 , wherein the urinary incontinence is overactive bladder syndrome.
4. The method for treating or preventing urinary incontinence according to claim 2 , wherein the urinary incontinence is overactive bladder syndrome.
5. The method for treating or preventing urinary incontinence according to claim 1 , wherein the urinary incontinence is urgency.
6. The method for treating or preventing urinary incontinence according to claim 1 , wherein the urinary incontinence is urge urinary incontinence.
7. The method for treating or preventing urinary incontinence according to claim 1 , wherein the urinary incontinence is stress urinary incontinence.
8. The method for treating or preventing urinary incontinence according to claim 1 , wherein the urinary incontinence is mixed urinary incontinence.
9. The method for treating or preventing urinary incontinence according to claim 2 , wherein the active ingredient 2 is an antimuscarinic agent 2a, vasopressin agonist 2b, Serotonin/Noradrenaline modulator 2c, or β3 agonist 2d.
10. The method for treating or preventing urinary incontinence according to claim 9 , wherein the active ingredient 2 is an antimuscarinic agent 2a.
11. The method for treating or preventing minary incontinence according to claim 10 , wherein the antimuscarinic agent 2a is Tolterodine, Oxybutynin, Darifenacin, Propiverine, Solifenacin, or Trospium, or a pharmaceutically acceptable acid addition salts, hydrates or solvate thereof.
12. The method for treating or preventing urinary incontinence according to claim 9 , wherein the active ingredient 2 is a vasopressin agonist 2b.
13. The method for treating or preventing urinary incontinence according to claim 12 , wherein the vasopressin agonists 2b is desmopressin, a pharmaceutically acceptable acid addition salt, hydrate, and/or solvate thereof.
14. The method for treating or preventing urinary incontinence according to claim 9 , wherein the active ingredient 2 is a Serotonin/Noradrenaline modulator 2c.
15. The method for treating or preventing urinary incontinence according to claim 14 , wherein the Serotonin/Noradrenaline modulator 2c is Venlafaxine, Duloxetine, Reboxetine, or Cizoliritine, or a pharmaceutically acceptable acid addition salts, hydrate, or solvate thereof.
16. The method for treating or preventing urinary incontinence according to claim 9 , wherein the active ingredient 2 is a β3 agonist 2d.
17. The method for treating or preventing urinary incontinence according to claim 16 , wherein the β3 agonist 2d is AD9677/TAK677, CL 316,243, SB 418790, L-796568, BMS-196085, BRL-35135A, CGP12177A, BTA-243, GW 427353, Trecanidine, Zeneca D7114, SR 59119, solabegron, CL616243, 2-[4-(2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acid, BRL37344A, or CGP-12177A, or a pharmaceutically acceptable acid addition salt, hydrate, or solvate thereof.