Devices and methods for delivery of electrical current for pain relief
Device/system that provides pain relief by delivering stimulation that neither generates action potentials nor completely blocks neural transmission (in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve) to alter the frequency of physiologically generated neural transmission.
1. A method of treating pain comprising:
deploying an open-coiled lead comprising an electrode, wherein the electrode is deployed outside of a central nervous system;
delivering electric current through the electrode to one peripheral nerve tissue;
altering, through the electric current, transmission and production of action potentials in the one peripheral nerve tissue, which is selected from a nerve cell body, dendrites, axons, axon hillocks, or other nerve fibers, wherein the altering occurs without directly stimulating an action potential in the peripheral nerve tissue; and
changing probability of action potentials occurring as a result of the electric current;
changing excitability of at least one nerve as a result of the electric current; and
changing conduction velocity, shape, or interpulse interval of action potentials as a result of the electric current and wherein the electrical current does not block or interrupt efferent signals and motor nerve signals.
2. The method of claim 1 , wherein the electrical current does not cause paresthesias.
3. The method of claim 1 wherein the electrical current alters action potentials in neural targets via activation, inactivation, excitation, or suppression of non-neural tissue.
4. The method of claim 3 wherein the non-neural tissue is a glial cell.
5. The method of claim 1 wherein the electrical current is delivered through the electrode located 1.0 mm or more away from the nerve tissue.
6. The method of claim 1 , wherein the electric current causes changes to a frequency of action potentials.
7. The method of claim 1 , wherein the electric current causes changes to form, features, period, rate, coefficient of variation, or duration of action potentials.
8. The method of claim 7 , wherein the electric current causes changes to timing, spacing, or pattern of action potentials or trains of action potentials.
9. The method of claim 1 , wherein the electric current causes changes to a frequency of action potentials and changes to form, features, period, rate, coefficient of variation, or duration of action potentials.
10. A method of treating pain comprising:
deploying an open-coiled lead into a tissue, the lead comprising an electrode positioned outside of a central nervous system;
altering transmission of action potentials in one peripheral nerve tissue selected from a nerve cell body (or soma), dendrites, axons, axon hillocks, or other nerve fibers
changing a probability of action potentials occurring through application of electrical stimulation via the electrode;
changing excitability of at least one nerve of said peripheral nerve tissue through the application of the electrical stimulation via the electrode; and
changing conduction velocity, shape, or interpulse interval of action potentials through the application of the electrical stimulation via the electrode wherein the electrical current does not block or interrupt efferent signals and motor nerve signals.
11. A method of treating pain comprising:
deploying an open-coiled lead into a tissue, the lead comprising an electrode positioned outside of a central nervous system;
delivering electric current to one peripheral nerve via the electrode;
altering transmission and production of action potentials in the one peripheral nerve tissue selected from a nerve cell body, dendrites, axons, axon hillocks, or other nerve fibers without directly stimulating an action potential in the peripheral nerve tissue;
changing probability action potentials occurring caused by the electric current;
changing excitability of at least one nerve caused by the electric current; and
changing conduction velocity, shape, interpulse interval of action potentials caused by the electric current and wherein the electrical current does not block or interrupt efferent signals and motor nerve signals.