Oligomer-beta blocker conjugates
View Patent ↗The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
1. A method of treating hypertension, cardiac arrhythmia, or migraines comprising:
administering an effective amount of a compound of the following formula to a patient in need thereof:
wherein:
R 1 is
R 2 is hydrogen;
R 3 is H;
R 4 is H;
R 5 is H;
R 6 is H;
R 7 is H;
Ar is
and
R 19 is
2. The method of claim 1 , wherein the compound is provided in a composition comprising a pharmaceutically acceptable excipient.
3. The method of claim 1 , wherein the compound is present in a dosage form.
4. The method of claim 1 , wherein the compound is
5. The method of claim 1 , wherein said administering comprises orally administering the compound.