IP Library › Granted Patent US 10,472,363
Granted Patent B2
US 10,472,363 · App. 15/693,758 · Granted Nov 12, 2019

SGC stimulators

Inventors: Glen Robert Rennie (Somerville, MA); Rajesh R. Iyengar (West Newton, MA); Thomas Wai-Ho Lee (Lexington, MA); Paul Allan Renhowe (Sudbury, MA); Joon Jung (Newton, MA)
Assignee: Cyclerion Therapeutics, Inc.
C07D487/04A61K31/437A61K31/4985A61K31/52C07D471/04C07D473/00
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Quick Facts
Patent No.
US 10,472,363
App. No.
15/693,758
Granted
Nov 12, 2019
Kind
B2
Abstract

The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I:

Claims (2)

1. A compound of Formula I-1, or a pharmaceutically acceptable salt thereof,

2. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient or carrier.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME FROM TISENTO THERAPEUTICS, INC. TO TISENTO THERAPEUTICS INC. PREVIOUSLY RECORDED ON REEL 064792 FRAME 0500. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 13, 2023
From: CYCLERION THERAPEUTICS, INC.
To: TISENTO THERAPEUTICS INC.
Reel/Frame 064889/0459 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 1, 2023
From: CYCLERION THERAPEUTICS, INC.
To: TISENTO THERAPEUTICS, INC.
Reel/Frame 064792/0500 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2019
From: IRONWOOD PHARMACEUTICALS, INC.
To: CYCLERION THERAPEUTICS, INC.
Reel/Frame 048853/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2018
From: RENNIE, GLEN ROBERT; IYENGAR, RAJESH R.; LEE, THOMAS WAI-HO; NAKAI, TAKASHI; MERMERIAN, ARA; JIA, LEI; IM, G-YOON JAMIE; RENHOWE, PAUL ALLEN; JUNG, JOON; GERMANO, PETER; IYER, KARTHIK; BARDEN, TIMOTHY CLAUDE; TANG, KIM
To: IRONWOOD PHARMACEUTICALS, INC.
Reel/Frame 045766/0135 →
Continuity (5)
Provisional Application 62482486 · Apr 6, 2017
Provisional Application 62468598 · Mar 8, 2017
Provisional Application 62423445 · Nov 17, 2016
Provisional Application 62382942 · Sep 2, 2016
Related Publication 20180065971A1 · Mar 8, 2018