METHODS OF TREATING UROLOGICAL DISORDERS USING SARMs
The present invention is directed to methods of treating, preventing, suppressing and/or inhibiting urological disorders such as urinary incontinence including stress urinary incontinence and pelvic floor disorders by administering a SARM compound of the invention.
1 . A method of treating, preventing, suppressing or inhibiting stress urinary incontinence in a postmenopausal female subject, comprising administering to said subject a SARM compound of Formula IX:
or its isomer, hydrate, pharmaceutically acceptable salt, pharmaceutical composition or any combination thereof.
2 . The method according to claim 1 , wherein said administering is of a composition comprising a 3 mg daily dose of said compound.
3 . A method of reducing the occurrence or lessening the severity of at least one of the following symptoms in a postmenopausal female subject suffering from stress urinary incontinence: (i) average daily frequency of urination; (ii) average nightly frequency of urination; (iii) total urinary incontinence episodes; (iv) stress incontinence episodes; and (v) urinary urgency episodes; comprising administering a SARM compound of Formula IX:
or its isomer, hydrate, pharmaceutically acceptable salt, pharmaceutical composition or any combination thereof.
4 . The method according to claim 3 wherein said administering is of a composition comprising a 3 mg daily dose of said compound.
5 . A method of treating, preventing, suppressing or inhibiting pelvic floor disorders in a postmenopausal female subject, comprising administering a SARM compound of Formula IX:
or its isomer, hydrate, pharmaceutically acceptable salt, pharmaceutical composition or any combination thereof.
6 . The method according to claim 5 , wherein said administering is of composition comprising a 3 mg daily dose of said compound.
7 . The method of claim 5 , wherein said pelvic floor disorder comprises cystocele, vaginal prolapse, vaginal hernia, rectocele, enterocele, uterocele, and/or urethrocele.
8 . A method of increasing the size and/or weight of muscles in the pelvic floor of a postmenopausal female subject, comprising administering a SARM compound of Formula IX:
or its isomer, hydrate, pharmaceutically acceptable salt, pharmaceutical composition or any combination thereof.
9 . The method according to claim 8 , wherein said administering is of composition comprising a 3 mg daily dose of said compound.
10 . The method of claim 8 , wherein said muscles comprise levator ani muscles, ischiococcygeus, coccygeus (COC) muscle, pubococcygeus (Pc) muscle, iliococcygeus (IL) muscle or any combination thereof.