IP Library Granted Patent US 10,672,298
Granted Patent B2
US 10,672,298 · App. 15/707,914 · Granted Jun 2, 2020

System and method for a blood flow simulator

Inventors: Robert Newberry (New Hope, AL); Matthew Rodencal (Huntsville, AL); Nate Roth (Toney, AL)
Assignee: SANMINA CORPORATION
G09B23/303A61B5/02A61B5/145A61B5/1495F03B13/14A61B2560/0223Y02E10/38
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,672,298
App. No.
15/707,914
Granted
Jun 2, 2020
Kind
B2
Abstract

A blood flow simulator generates a compression and expansion in a test fluid that emulates the pressure waveform created by a heartbeat in blood flow. The blood flow simulator stores a plurality of pressure waveform files that include actual data recorded from a heartbeat, arterial pressure waveform, or venous pressure waveform. One or more of the pressure waveform files may be selected and the pressure waveform file is used by the blood flow simulator 100 to generate a pressure waveform in pressurized fluid. The pressurized fluid flows through a test site, such as a surrogate body part or an optical window or other component with material having similar properties to human tissue. Various target substances may also be added to the fluid in known concentrations for testing and configuration of medical devices at the test site.

Claims (42)

1. A blood flow simulator, comprising:

a system controller including a memory for storing a plurality of pressure waveform files;

a pressure waveform generator configured to generate a pressure waveform; and

an optical bladder including an optical window test bed, wherein the optical bladder is configured to induce the pressure waveform in fluid in the optical window test bed in response to at least one of the plurality of pressure waveform files;

an acoustic induction bladder, wherein the pressure waveform generator is configured to generate the pressure waveform in gas in the acoustic induction bladder in response to the at least one of the plurality of pressure waveform files; and

an induction coupler situated between the acoustic induction bladder and the optical bladder, wherein the induction coupler is configured to exert pressure onto the optical bladder in response to the pressure waveform in the gas in the acoustic induction bladder.

2. The blood flow simulator of claim 1 , wherein the optical window test bed comprises a material with elasticity and optical properties similar to human tissue.

3. The blood flow simulator of claim 1 , wherein the plurality of pressure waveform files includes data from at least one of: a heart rate, a heartbeat waveform, an arterial blood pressure waveform, a respiration waveform, a background tissue response waveform, or a venous blood pressure waveform.

4. The blood flow simulator of claim 1 , wherein the plurality of pressure waveform files includes data indicative of arrhythmia, including at least one of: an accelerated heartrate, a low heart rate, or an irregular cardiac rhythm.

5. The blood flow simulator of claim 1 , wherein the pressure waveform generator comprises:

a pressure bladder configured to hold gas;

an amplifier for amplifying data from at least one of the plurality of pressure waveform files to generate an amplified data signal; and

a pressure inducer configured to compress the pressure bladder in response to the amplified data signal to generate the pressure waveform in the gas.

6. The blood flow simulator of claim 5 , wherein the pressure waveform generator further comprises:

at least one actuator configured to exert pressure on the pressure inducer in response to the amplified data signal.

7. The blood flow simulator of claim 6 , wherein the at least one actuator includes at least one of: a piezoelectric actuator or an electromagnetic actuator.

8. The blood flow simulator of claim 1 , further comprising:

an injection valve configured for injecting a target substance into the fluid to obtain a known concentration of the target substance in the fluid.

9. The blood flow simulator of claim 1 , further comprising:

one or more pressure sensors configured to measure a pressure in the fluid and generate a feedback signal to the system controller.

10. The blood flow simulator of claim 9 , wherein the system controller further includes:

a signal processor configured to receive the feedback signal from the one or more pressure sensors and generate a pre-distortion signal for a distortion compensation filter to obtain a data signal from the at least one of the pressure waveform files.

11. A method for simulating blood flow in a vessel, comprising:

processing by a system controller a selection of one of a plurality of pressure waveform files stored in a memory;

generating by a pressure waveform generator a pressure waveform in gas in an acoustic induction bladder using the selected one of the plurality of pressure waveform files; and

inducing by an optical bladder the pressure waveform in fluid within an optical window test bed in the optical bladder; and

exerting pressure by an induction coupler onto the optical bladder in response to the pressure waveform in the gas, wherein the induction coupler is situated between the acoustic induction bladder and the optical bladder.

12. The method of claim 11 , wherein the optical window test bed comprises a material with elasticity and optical properties similar to human tissue.

13. The method of claim 12 , wherein the plurality of pressure waveform files includes data from at least one of: a heart rate, a heartbeat waveform, an arterial blood pressure waveform, a respiration waveform, a background tissue response waveform, or a venous blood pressure waveform.

14. The method of claim 11 , wherein the plurality of pressure waveform files includes data indicative of arrhythmia, including at least one of: an accelerated heartrate, a low heart rate, or an irregular cardiac rhythm.

15. The method of claim 11 , further comprising:

amplifying data by an amplifier from the selected one of the plurality of pressure waveform files to generate an amplified data signal; and

compressing a pressure bladder using a pressure inducer in response to the amplified data signal to generate the pressure waveform in gas within the pressure bladder.

16. The method of claim 15 , further comprising:

exerting pressure by at least one actuator on the pressure inducer in response to the amplified data signal.

17. The method of claim 16 , wherein the at least one actuator includes at least one of: a piezoelectric actuator or an electromagnetic actuator.

18. The method of claim 11 , further comprising:

injecting a target substance into the fluid to obtain a known concentration of the target substance in the fluid.

19. The method of claim 11 , further comprising:

detecting a pressure in the fluid and generating a feedback signal to the system controller;

generating a pre-distortion signal for a distortion compensation filter to filter a data signal from the selected one of the pressure waveform files; and

generating by the pressure waveform generator the pressure waveform using the filtered data signal.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 26, 2021
From: SANMINA CORPORATION
To: TRILINEAR BIOVENTURES, LLC
Reel/Frame 056364/0506 →
SECURITY INTEREST Recorded May 11, 2021
From: TRILINEAR BIOVENTURES, LLC
To: SANMINA CORPORATION
Reel/Frame 056205/0739 →
RELEASE OF SECURITY INTEREST Recorded Jun 5, 2019
From: U.S. BANK NATIONAL ASSOCIATION, SOLELY AS NOTES COLLATERAL AGENT
To: SANMINA CORPORATION; HADCO CORPORATION; HADCO SANTA CLARA; SCI TECHNOLOGY; SENSORWISE, INC.
Reel/Frame 049378/0927 →
SECURITY INTEREST Recorded Nov 8, 2017
From: SANMINA CORPORATION
To: U.S. BANK NATIONAL ASSOCIATION, NOT IN ITS INDIVIDUAL CAPACITY BUT SOLELY AS NOTES COLLATERAL AGENT
Reel/Frame 044074/0113 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2017
From: NEWBERRY, ROBERT STEVEN; RODENCAL, MATTHEW; ROTH, NATE
To: SANMINA CORPORATION
Reel/Frame 043648/0392 →
Continuity (2)
Provisional Application 62409271 · Oct 17, 2016
Related Publication 20180108275A1 · Apr 19, 2018