Anatomical targeting of neuromodulation
A neuromodulation targeting system includes a GUI that facilitates selection of one or more neuromodulation target regions. The GUI provides an interactive display representing anatomy of a patient with user-selectable portions corresponding to a plurality of predefined anatomical regions associated with distinct localized clinical effects of neuromodulation. The system further includes a targeting selector engine that is responsive to user selection of a first portion of the interactive display by configuring delivery of neuromodulation therapy to a first target region to produce a first localized clinical effect in the patient at a location corresponding to the first portion of the display, upon administration of the neuromodulation therapy to the patient.
1. A neuromodulation targeting system facilitating spatial selection of a neuromodulation objective for a neuromodulation therapy to be delivered by a neuromodulation device, the system comprising:
a graphical user interface (GUI) that includes an interactive display representing anatomy of a patient with user-selectable anatomic sites associated with a plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation, wherein the interactive display includes at least one of a dermatomal map of the patient with individually-selectable dermatomes, a spinal map of the patient with selectable portions of dorsal roots, or a map of fiber tracts proximate the spinal cord with selectable portions of the fiber tracts; and
a targeting selector engine operatively coupled with the GUI, the targeting selector engine being responsive to user selection of a first anatomic site to:
computationally determine a first target region where the neuromodulation therapy is to be directed, the first target region being distinct from an anatomic location corresponding to the user-selected first anatomic site, and
configure delivery of the neuromodulation therapy by the neuromodulation device to the first target region to produce a first localized clinical effect in the patient at the anatomic location corresponding to the user-selected first anatomic site, upon administration of the neuromodulation therapy to the patient, to achieve the neuromodulation objective,
wherein the interactive display further includes a therapy type selector input facilitating a user-selection of neuromodulation type for each selected site from the user-selectable anatomic sites, the user-selection of neuromodulation type including a user-selection from among paresthesia neuromodulation and sub-perception neuromodulation.
2. The neuromodulation targeting system of claim 1 , wherein the first target region is a neuroanatomic region selected from the group consisting of: a dorsal column region, a dorsal root region, a dorsal horn region, a dermatomic region, or any combination thereof.
3. The neuromodulation targeting system of claim 1 , wherein the plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation include dermatomes.
4. The neuromodulation targeting system of claim 1 , wherein the first anatomic site represents a site where pain is reported by the patient.
5. The neuromodulation targeting system of claim 1 , wherein the interactive display representing anatomy of the patient includes the dermatomal map of the patient with individually-selectable dermatomes.
6. The neuromodulation targeting system of claim 1 , wherein the interactive display representing anatomy of the patient further includes the spinal map of the patient with selectable portions of dorsal roots.
7. The neuromodulation targeting system of claim 1 , wherein the interactive display representing anatomy of the patient includes the map of fiber tracts proximate the spinal cord with selectable portions of the fiber tracts.
8. The neuromodulation targeting system of claim 1 , wherein the interactive display representing the anatomy of the patient is based on actual measured anatomic characteristics of the patient.
9. The neuromodulation targeting system of claim 1 , wherein the interactive display further facilitates selection of an exclusion zone of the anatomy of the patient that is to be free of one or more specified types of neuromodulation.
10. The neuromodulation targeting system of claim 1 , further comprising:
an electrotherapy parameter selector engine configured to determine an electrical signal waveform to be applied to the first target region, the electrical signal waveform being specific to a neurologic structure present at the first target region.
11. The neuromodulation targeting system of claim 10 , wherein the electrotherapy parameter selector engine is further configured to determine the electrical signal waveform based on an activation function associated with the neurologic structure at the first target region.
12. The neuromodulation targeting system of claim 11 , wherein the electrotherapy parameter selector engine is configured to determine the electrical signal waveform based on an orientation of the neurologic structure at the first target region relative to a location of a set of electrodes from which the neuromodulation therapy is to be directed.
13. The neuromodulation targeting system of claim 10 , wherein the GUI includes a treatment objective input to accept a clinical effect objective specified by a user; and
wherein the electrotherapy parameter selector engine is further configured to determine the electrical signal waveform based on the clinical effect objective.
14. The neuromodulation targeting system of claim 1 , wherein the first localized clinical effect includes at least one effect selected from the group consisting of: pain relief, paresthesia, natural-touch simulation, or any combination thereof.
15. In a neuromodulation targeting system, a method for facilitating spatial selection of a neuromodulation objective, the method comprising:
providing a graphical user interface (GUI) that includes an interactive display representing anatomy of a patient with user-selectable anatomic sites associated with a plurality of predefined neural pathways corresponding to distinct localized clinical effects of neuromodulation, wherein the interactive display includes at least one of a dermatomal map of the patient with individually-selectable dermatomes, a spinal map of the patient with selectable portions of dorsal roots, or a map of fiber tracts proximate the spinal cord with selectable portions of the fiber tracts, and wherein the interactive display further includes a therapy type selector input facilitating a user-selection of neuromodulation type for each selected site from the user-selectable anatomic sites, the user-selection of neuromodulation type including a user-selection from among paresthesia neuromodulation and sub-perception neuromodulation; and
responding to user selection of a first anatomic site, including:
computationally determining a first target region where neuromodulation therapy is to be directed, the first target region being distinct from an anatomic location corresponding to the user-selected first anatomic site, and
configuring the neuromodulation therapy for delivery to the first target region to produce a first localized clinical effect in the patient at the anatomic location corresponding to the user-selected first anatomic site, upon administration of the neuromodulation therapy to the patient, to achieve the neuromodulation objective.
16. The method of claim 15 , further comprising:
determining an electrical signal waveform to be applied to the first target region, the electrical signal waveform being specific to a neurologic structure present at the first target region.
17. The method of claim 16 , further comprising:
determining the electrical signal waveform based on an activation function associated with the neurologic structure at the first target region.
18. The method of claim 17 , further comprising:
determining the electrical signal waveform based on an orientation of the neurologic structure at the first target region relative to a location of a set of electrodes from which the neuromodulation therapy is to be directed.
19. The method of claim 16 , wherein the GUI includes a treatment objective input to accept a clinical effect objective specified by a user; further comprising:
determining the electrical signal waveform based on the clinical effect objective.
20. The method of claim 15 , wherein the interactive display further facilitates selection of an exclusion zone of the anatomy of the patient that is to be free of one or more specified types of neuromodulation.