Platinum compounds, compositions, and uses thereof
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein, engineered protein, antibody, antibody fragment, peptide, agonist, antagonist, aptamer or ligand which may be capable of recognizing a selected target cell population, and/or derivatives/analogs/mimics thereof.
1. A method of synthesizing
the method comprising:
a. synthesizing
from cisplatin;
b. synthesizing
from 6-maleimidohexanoic acid and diphenylphosphoryl azide (DPPA); and
c. synthesizing compound 8 from compound 1′ and compound 2′.
2. The method of claim 1 , further comprising purifying compound 8 with precipitation.
3. The method of claim 1 , wherein the method comprises purifying compound 2′ to remove DPPA and any DPPA by-products.
4. The method of claim 1 , wherein compound 1′ is washed with isopropanol (IPA) and methyl tertiary-butyl ether (MTBE).
5. The method of claim 1 , wherein the method does not comprise any chromatography or lyophilization step.
6. The method of claim 1 , wherein the purity of compound 8 is at least about 95%.
7. The method of claim 1 , wherein the yield of compound 8 is at least about 85% and between about 0.1-about 1 kg.