IP Library › Granted Patent US 10,259,819
Granted Patent B2
US 10,259,819 · App. 15/721,167 · Granted Apr 16, 2019

Process for preparing oxycodone compositions

Inventors: Robert Chapman (Downingtown, PA); Lonn S. Rider (Foster, RI); Qi Hong (Sharon, MA); Donald Kyle (Yardley, PA); Robert Kupper (East Greenwich, RI)
Assignees: PURDUE PHARMA L.P.; THE P.F. LABORATORIES, INC.; PURDUE PHARMACEUTICALS L.P.; RHODES TECHNOLOGIES
C07D489/08A61K9/14A61K9/20A61K9/2095A61K9/48A61K9/4833A61K31/485C07D489/02C07D489/04
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Quick Facts
Patent No.
US 10,259,819
App. No.
15/721,167
Granted
Apr 16, 2019
Kind
B2
Abstract

In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

Claims (2)

1. A process for preparing an oxycodone hydrochloride composition comprising, (i) reacting an oxycodone base composition with one or more acids selected from the group consisting of tartaric acid, oxalic acid, fumaric acid, phosphoric acid and sulfuric acid to form a corresponding acid addition salt of oxycodone; and (ii) converting the acid addition salt into oxycodone hydrochloride.

2. The process of claim 1 , wherein step (i) comprises reacting the oxycodone base composition with sulfuric acid.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2019
From: THE P.F. LABORATORIES, INC.; PURDUE PHARMA TECHNOLOGIES, INC.
To: PURDUE PHARMA L.P.
Reel/Frame 048936/0093 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2019
From: CHAPMAN, ROBERT; RIDER, LONN S.; HONG, QI; KYLE, DONALD; KUPPER, ROBERT
To: EURO-CELTIQUE S.A.
Reel/Frame 048171/0713 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2019
From: EURO-CELTIQUE S.A.
To: PURDUE PHARMA L.P.
Reel/Frame 048171/0746 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2019
From: PURDUE PHARMA L.P.
To: PURDUE PHARMA L.P.; THE P.F. LABORATORIES, INC.; PURDUE PHARMACEUTICALS L.P.; RHODES TECHNOLOGIES
Reel/Frame 048171/0807 →
Continuity (14)
Continuation 15058420 · Mar 2, 2016
Continuation 14725210 · May 29, 2015
Continuation 13366755 · Feb 6, 2012
Continuation 12893681 · Sep 29, 2010
Continuation 12380800 · Mar 4, 2009
Continuation 11635529 · Jan 16, 2007
Continuation 11391897 · Mar 29, 2006
Continuation 11093626 · Mar 30, 2005
Provisional Application 60651778 · Feb 10, 2005
Provisional Application 60648625 · Jan 31, 2005
Provisional Application 60620072 · Oct 18, 2004
Provisional Application 60601534 · Aug 13, 2004
Provisional Application 60557492 · Mar 30, 2004
Related Publication 20180022754A1 · Jan 25, 2018