Butyrate Based Skin Formulation
A topical composition for the treatment of inflammatory skin conditions including a butyrate active ingredient and a dermatologically acceptable carrier. The compositions include about 0.01 w/w % to about 20 w/w % butyrate, preferably a butyrate metal salt, and are free of a steroid. The compositions can be to the skin of a patient in need thereof in a method of treating inflammatory conditions of the skin.
1 . A topical composition for the treatment of inflammatory skin conditions comprising a butyrate active ingredient and a dermatologically acceptable carrier, wherein the composition is substantially free of a steroid.
2 . The topical composition of claim 1 , wherein the butyrate active ingredient is a butyric acid, a butyrate salt, or hydrates thereof.
3 . The topical composition of claim 2 , wherein the butyrate active ingredient is a metal butyrate salt.
4 . The topical composition of claim 3 , wherein the butyrate active ingredient is sodium butyrate.
5 . The topical composition of claim 3 , wherein the butyrate active ingredient is potassium butyrate.
6 . The topical composition of claim 3 , wherein the butyrate active ingredient is lithium butyrate.
7 . The composition of claim 1 , wherein the composition comprises about 0.01 w/w % to about 20 w/w % butyrate.
8 . The composition of claim 7 , wherein the composition comprises about 0.05 w/w % to about 10.0 w/w % butyrate.
9 . The composition of claim 8 , wherein the composition comprises about 0.1 w/w % to about 5.0 w/w % of butyrate.
10 . The composition of claim 1 , wherein the composition is free of a feverfew extract.
11 . The composition of claim 1 , further comprising a fragrance.
12 . The composition of claim 11 , wherein the fragrance is a natural oil.
13 . The composition of claim 12 , wherein the oil is a grapefruit-based oil.
14 . The composition of claim 1 , wherein the composition is a lotion or cream.
15 . A method of treating inflammatory conditions of the skin comprising administering a topical composition of claim 1 to the skin of a patient in need thereof.
16 . A method of making the topical butyrate composition of claim 1 comprising the steps of:
premixing a first mixture of water and thickener until it becomes homogeneous;
adding a second mixture comprising moisturizer and conditioner to the first mixture and mixing until the two mixtures become homogeneous;
premixing a third mixture comprising emollient, moisturizer, emulsifier, conditioner, skin barrier and preservative until it becomes homogeneous;
heating the third mixture and adding it to the first and second mixtures to form a fourth mixture;
mixing in a pH-neutralizer to the fourth mixture and letting the mixture cool; and
adding the butyrate active ingredient and fragrance to the fourth mixture.
17 . The method of claim 16 , wherein the heating is to a temperature of about 75° C.
18 . The method of claim 16 , wherein the cooling is to a temperature of about 50° C.
19 . A topical composition for the treatment of inflammatory skin conditions comprising about 0.1 w/w % of a butyrate metal salt and a dermatologically acceptable carrier, wherein the composition is free of a steroid.
20 . The composition of claim 19 , wherein the butyrate metal salt is sodium butyrate.