Apparatus for treating asthma using neurotoxin
Apparatus and methods for providing intrabronchial delivery of a treatment fluid to control the effects of a bronchial condition. The apparatus can include a shaft having proximal and distal ends and a fluid injection assembly disposed on the distal end. The fluid injection assembly can be a deployable needle assembly, a rotating needle assembly, a needle-less injection assembly, or a nebulizer assembly.
1. A delivery device for delivering a pressurized treatment fluid to a target treatment area of a wall of an airway to treat a bronchial condition, the target treatment area extending only a portion of a circumference of the airway, the delivery device comprising:
a shaft having a proximal end including an inlet port, a distal end and a lumen extending between the inlet port and the distal end;
a needle-less injection assembly coupled to the distal end of the shaft on a first side of the shaft, and comprising at least one fluid injector in fluid communication with the lumen of the shaft; and
a deflection mechanism disposed on a side of the shaft opposite the needle-less injection assembly, the deflection mechanism being configured to align the shaft with the target treatment area and urge the shaft and the at least one fluid injector adjacent to and in contact with the wall of the airway at a first contact area radially inward from the target treatment area by contacting the wall of the airway at a second contact area, the second contact area being opposite the airway from the first contact area, wherein the deflection mechanism is configured to contact the second contact area and not the first contact area, and
wherein the at least one fluid injector is configured to directly inject the pressurized treatment fluid from the lumen across an epithelium of the wall of the airway at the first contact area and to the target treatment area while the at least one fluid injector is in contact with the wall of the airway to alter the target treatment area so as to treat the bronchial condition.
2. The delivery device of claim 1 , wherein the deflection mechanism is an inflatable balloon.
3. The delivery device of claim 1 , wherein the at least one fluid injector comprises at least one port configured to be placed in apposition to the target treatment area and to deliver a pressurized gas across the epithelium and to the target treatment area.
4. The delivery device of claim 1 , wherein the needle-less injection assembly comprises a plurality of needle-less injectors arranged along the shaft so as to be placed in apposition to the wall of the airway in different locations along the airway at the first contact area.
5. The delivery device of claim 1 , wherein the shaft is either pre-curved or actively curved with an activation mechanism to urge the at least one fluid injector adjacent to or against the wall of the airway at the first contact area.
6. The delivery device of claim 1 , wherein the pressurized treatment fluid comprises a neurotoxin.
7. A system comprising the delivery device of claim 1 , further comprising a bronchoscope having proximal and distal ends, a lumen extending therebetween, wherein the shaft is dimensioned to slidably pass through the lumen of the bronchoscope.
8. A system comprising the delivery device of claim 1 , further comprising a controller coupled to the proximal end of the shaft, and configured to deliver a desired dose of the pressurized treatment fluid to the target treatment area.