Use of FGF19 to increase muscle fiber size
The present invention relates to an FGF19 polypeptide for use in increasing muscle fiber size in the treatment of muscle atrophy in a mammal.
1. A method for increasing the muscle fiber size in a mammal wherein the mammal has muscle atrophy, said method comprising administering an effective amount of a fibroblast growth factor 19 (FGF19) polypeptide to the mammal.
2. The method according to claim 1 , wherein the mammal is a human.
3. The method according to claim 1 , wherein an increase in muscle mass in the mammal is observed.
4. The method according to claim 1 , wherein the mammal is not a human.
5. The method according to claim 1 , wherein muscle strength is increased in the mammal.
6. The method according to claim 1 , wherein the FGF19 polypeptide has an amino acid sequence selected from the group consisting of SEQ ID NO:1-10.
7. The method according to claim 1 , wherein the muscle atrophy is caused by cachexia.
8. The method according to claim 1 , wherein the muscle atrophy is caused by sarcopenia.
9. The method according to claim 1 , wherein the muscle atrophy is caused by prolonged immobilization.
10. The method according to claim 1 , wherein the muscle atrophy is caused by obesity.
11. The method according to claim 1 , wherein the mammal is a bovine.
12. A method for increasing the muscle fiber size in a mammal wherein the mammal has muscle atrophy, said method comprising administering an effective amount of a pharmaceutical composition comprising and FGF19 polypeptide and a pharmaceutically-acceptable vehicle to the mammal.
13. The method according to claim 12 , wherein the pharmaceutical composition further comprises a drug for treating cachexia, a performance-enhancing drug, a nutritional supplement, a solution of amino acids, or protein hydrolysates.