Proteins and immunizing compositions containing
Provided herein are isolated proteins isolatable from a Klebsiella spp. Also provided are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.
1. A composition comprising:
a first isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:41, a second isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:42, a third isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:43, and a fourth isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:44;
a protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:58, SEQ ID NO:61, or SEQ ID NO:64; and
an effective amount of an adjuvant.
2. The composition of claim 1 further comprising a fifth isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:54 and a sixth isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:55.
3. The composition of claim 1 further comprising a protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:58, SEQ ID NO:61, or SEQ ID NO:64.
4. A kit, comprising in separate containers:
a first isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:41, a second isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:42, a third isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:43, and a fourth isolated protein comprising an amino acid sequence that has at least 80% identity with SEQ ID NO:44.
5. The composition of claim 1 wherein the first isolated protein comprises an amino acid sequence that has at least 90% identity with SEQ ID NO:41, the second isolated protein comprises an amino acid sequence that has at least 90% identity with SEQ ID NO:42, the third isolated protein comprises an amino acid sequence that has at least 90% identity with SEQ ID NO:43, and the fourth isolated protein comprises an amino acid sequence that has at least 90% identity with SEQ ID NO:44.
6. The composition of claim 2 wherein the fourth isolated protein comprises an amino acid sequence that has at least 90% identity with SEQ ID NO:54, and the sixth isolated protein comprises an amino acid sequence that has at least 90% identity with SEQ ID NO:55; and
a protein comprising an amino acid sequence that has at least 90% identity with SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:58, SEQ ID NO:61, or SEQ ID NO:64.
7. The composition of claim 5 further comprising a protein comprising an amino acid sequence that has at least 90% identity with SEQ ID NO:45, SEQ ID NO:46, SEQ ID NO:49, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:58, SEQ ID NO:61, or SEQ ID NO:64.