Compositions, kits, and methods using interleukin-17C to promote neural growth and/or neural survival
View Patent ↗The present disclosure provides compositions, kits, and methods of promoting neural growth and/or neural survival using IL-17c. The compositions, kits, and methods can be used to promote neural growth and/or neural survival in a variety of conditions where such growth and survival is beneficial.
1. A method of promoting neural growth and/or neural survival in a subject in response to a herpes simplex virus (HSV) viral infection, the method comprising administering to the subject a therapeutically effective amount of an IL-17c protein thereby promoting neural growth and/or neural survival in the subject.
2. The method of claim 1 , wherein the neural growth is evidenced by nerve density, neurite growth and/or neurite guidance.
3. The method of claim 1 , wherein the IL-17c protein comprises SEQ ID NO: 1.
4. The method of claim 1 , wherein the promoted neural growth and/or neural survival is found in a sensory or motor neural cell and/or nerve.
5. The method of claim 4 , wherein the administering is in or around a site of the sensory or motor neural cell and/or nerve.
6. The method of claim 1 , wherein the administering is topical.
7. The method of claim 1 , wherein the administering is through application of a transdermal patch.
8. The method of claim 1 , wherein the administering is prophylactic.
9. The method of claim 1 wherein the promoting alleviates a symptom of neurodegeneration.
10. The method of claim 9 wherein the neurodegeneration is a peripheral neuropathy.
11. A method of promoting neural growth and/or neural survival in response to a herpes simplex virus (HSV) viral infection, the method comprising contacting a neural cell or nerve with a therapeutically effective amount of an IL-17c protein thereby promoting neural growth and/or neural survival.
12. The method of claim 11 , wherein the neural growth and/or neural survival is evidenced by increased neural cell survival, increased neurite growth, neurite guidance, and/or increased innervation.
13. The method of claim 11 , wherein the IL-17c protein comprises SEQ ID NO: 1.
14. The method of claim 11 , wherein the neural cell or nerve is from:
the peripheral nervous system; and/or
a sensory or motor neural cell or nerve; and/or
within the dermis of a subject.
15. The method of claim 14 , wherein the subject is a subject in need of the promoting neural growth and/or neural survival.
16. A method of reducing and/or delaying chemotherapy-associated neuron apoptosis in a cell in vitro, comprising:
administering to the cell in vitro, before a dose of chemotherapy, a therapeutically effective amount of an IL-17c protein,
thereby reducing and/or delaying chemotherapy-associated neuron apoptosis in the cell.
17. The method of claim 16 , wherein the IL-17c protein comprises SEQ ID NO: 1.