COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS
The invention relates to novel veterinary compositions comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound. The invention also relates to the use of such compositions for controlling ectoparasites in a non-human mammal.
1 . A veterinary composition comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound.
2 . The veterinary composition according to claim 1 , wherein the neonicotinoid compound is dinotefuran, derivatives, metabolites or salts thereof.
3 . The veterinary composition according to claim 1 , wherein the N-arylpyrazole compound is fipronil, derivatives, metabolites or salts thereof.
4 . The veterinary composition according to claim 1 , wherein the ratio of the neonicotinoid compound to the N-arylpyrazole compound is from about 6:1 to about 1:6, preferably from about 2:1 to about 1:3.
5 . The veterinary composition according to claim 1 , wherein the ratio of the neonicotinoid compound to the N-arylpyrazole compound is about 1:1.5.
6 . A method for controlling ectoparasites in a non-human mammal comprising administering to said non-human mammal a veterinary composition comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound.
7 . The method according to claim 6 , wherein the ectoparasites are fleas and/or ticks.
8 . The method according to claim 6 , wherein the non-human mammal is a dog or a cat.
9 . The method according to claim 6 , wherein the composition is administered by topical application.
10 . The method according to claim 6 , wherein the composition is a spot-on, a pour-on or a line-on composition.
11 . A method for treating ectoparasites infestations in a non-human mammal comprising administering to said non-human mammal a veterinary composition comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound.
12 . A kit comprising (a) one compartment comprising a neonicotinoid compound, preferably dinotefuran, derivatives, metabolites or salts thereof and (b) a second compartment comprising a N-arylpyrazole compound, preferably fipronil, derivatives, metabolites or salts thereof, as a combined preparation for simultaneous, separate or sequential use, in particular for controlling ectoparasites in a non-human mammal.
13 . The kit according to claim 12 , wherein the amounts of the neonicotinoid compound in (a) and N-arylpyrazole in (b) are such that the ratio of the neonicotinoid compound to the N-arylpyrazole compound is from about 6:1 to about 1:6, preferably from about 2:1 to about 1:3, more preferably about 1:1.5.
14 . The kit according to claim 12 , wherein it further comprises a package leaflet or user instruction including the information that said preparation is to be used for controlling ectoparasites, preferably fleas and/or ticks in a non-human mammal, preferably in a dog or a cat.