Hemichannel extracellular-domain specific agents for treating sepsis
Methods of treating sepsis or endotoxemia in a subject comprising administering to the subject an amount of an antagonist of a Panx1 hemichannel protein or an amount of an antagonist of a Cx43 hemichannel protein.
1. A method of treating sepsis or endotoxemia in a subject or of reducing or inhibiting development of sepsis in a subject, the method comprising administering to the subject an amount of a peptide consisting of the sequence ENVCYD (SEQ ID NO:1) sufficient to treat sepsis or endotoxemia, or sufficient to reduce or inhibit development of sepsis.
2. The method of claim 1 , wherein the subject already has sepsis and the method is to treat sepsis in the subject.
3. The method of claim 1 , wherein the method is to reduce or inhibit development of sepsis in the subject.
4. The method of claim 1 , wherein carbenoxolone, glycyrrhizic acid, glycyrrhitinic acid, or monoammonium glycyrrhizinate is also administered.