Polymer composition, article, medical device, article production method, and cell cluster production method

1. An article comprising, on at least a part of a surface thereof, a polymer having repeating units (A) and (B),

wherein said article is one selected from the group consisting of a medical device, a cell culture equipment, and a silicone substrate;

(A) is a hydrophilic repeating unit; and

(B) is a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms, and

wherein the article is a silicone substrate which has a microchannel.

2. The article according to claim 1 ,

wherein said repeating unit (A) is at least one selected from the group consisting of a repeating unit (A-1) represented by Formula (1), a repeating unit (A-2) represented by Formula (2), a repeating unit (A-3) represented by Formula (3), a repeating unit (A-4) represented by Formula (4), a repeating unit (A-5) represented by Formula (5), a repeating unit (A-6) represented by Formula (6), an anionic repeating unit (A-7), and a repeating unit (A-8) represented by Formula (8):

wherein, R 1 represents an alkylene group having 2 to 4 carbon atoms; R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 3 represents a hydrogen atom or a methyl group; R 4 represents —O—, *—(C═O)—O—, *—(C═O)—NR 5 —, *—NR 5 —(C═O)— where R 5 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and * represents a position at which the group is bound to a carbon atom bound with R 3 in the Formula (1), or a phenylene group; and n represents a value of 2 to 100;

wherein, R 6 represents a hydrogen atom or a methyl group; R 7 represents an alkylene group having 2 to 4 carbon atoms; R 8 represents an alkylene group having 1 to 10 carbon atoms; R 9 , R 10 and R 11 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 8 carbon atoms; and q represents a value of 1 to 10;

wherein, R 12 represents a hydrogen atom or a methyl group; and R 13 and R 14 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or hydroxyalkyl group;

wherein, R 15 represents a hydrogen atom or a methyl group; and R 16 and R 17 each independently represent an alkylene group having 1 to 3 carbon atoms;

wherein, R 18 represents an alkylene group having 1 to 5 carbon atoms;

wherein, Y represents —(C═O)O − , —(O═S═O)O − , —O(O═S═O)O − , —(S═O)O − , —O(S═O)O − , —OP(═O)(OR 24 )O − , —OP(═O)(R 24 )O − , —P(═O)(OR 24 )O − , or —P(═O)(R 24 )O − where R 24 represents an alkyl group having 1 to 3 carbon atoms; R 19 represents a hydrogen atom or a methyl group; R 2 ° represents a divalent organic group having 1 to 10 carbon atoms; R 21 and R 22 each independently represent a hydrocarbon group having 1 to 10 carbon atoms; and R 23 represents a divalent organic group having 1 to 10 carbon atoms; and

wherein, R 25 represents a hydrogen atom or a methyl group; R 26 represents —O—, *—(C═O)—O—, *—(C═O)—NR 31 —, *—NR 31 —(C═O)— where R 31 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and * represents a position at which the group is bound to a carbon atom bound with R 25 in the Formula (8), or a phenylene group; R 27 represents a divalent organic group having 1 to 10 carbon atoms; and R 28 , R 29 and R 30 each independently represent a hydrocarbon group having 1 to 10 carbon atoms, wherein the repeating unit (A-8) has a counter ion.

3. The article according to claim 2 , wherein in Formula (1), R 4 represents *—(C═O)—O— and * represents a position at which the group is bound to a carbon atom bound with R 3 in the Formula (1), or a phenylene group.

4. The article according to claim 1 , wherein said repeating unit (B) is a repeating unit derived from a monomer having an ethylenically unsaturated bond.

5. The article according to claim 1 , wherein said repeating unit (B) is represented by Formula (b2):

wherein, R 32 represents an alkylene group having 2 to 4 carbon atoms; R 33 represents an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms; R 34 represents a hydrogen atom or a methyl group; R 35 represents —O—, **—(C═O)—O—, **—(C═O)—NR 36 —, **—NR 36 —(C═O)— where R 36 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and ** represents a position at which the group is bound to a carbon atom bound with R 34 in the Formula (b2), or a phenylene group; and m represents a value of 2 to 100.

6. The article according to claim 1 , wherein said polymer further comprises at least one repeating unit (C) selected from the group consisting of a repeating unit (C-1) represented by Formula (c1) and a repeating unit (C-2) having a group represented by Formula (c2) at a side chain terminal:

wherein, R 37 represents a hydrogen atom or a methyl group; R 38 represents —O—, ***—(C═O)—O—, ***—(C═O)—NR 40 —, ***—NR 40 —(C═O)— where R 40 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and *** represents a position at which the group is bound to a carbon atom bound with R 37 in the Formula (c1), or a phenylene group; and R 39 represents a hydrocarbon group having 4 to 30 carbon atoms; and

wherein, R 41 represents a divalent organic group having 1 to 10 carbon atoms; R 42 and R 43 each independently represent an organic group having 1 to 10 carbon atoms; R 44 , R 45 and R 46 each independently represent —OSi(R 49 ) 3 where each R 49 independently represents a hydrogen atom or an organic group having 1 to 8 carbon atoms, or an organic group having 1 to 10 carbon atoms; and r represents a value of 0 to 200.

7. The article according to claim 1 , wherein said polymer is soluble in water.

8. A method of producing an article selected from the group consisting of a medical device, a cell culture equipment and a silicone substrate, said method comprising

arranging a polymer having repeating units (A) and (B) on at least a part of a surface of the article,

wherein

(A) is a hydrophilic repeating unit; and

(B) is a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms,

wherein the article is a silicone substrate which has a microchannel.

9. The method according to claim 8 ,

wherein

(A) is a hydrophilic repeating unit; and

(B) is a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is an alkyl group having 5 to 30 carbon atoms, or an alkanoyl group having 5 to 30 carbon atoms wherein said repeating unit (A) is at least one selected from the group consisting of a repeating unit (A-1) represented by Formula (1), a repeating unit (A-2) represented by Formula (2), a repeating unit (A-3) represented by Formula (3), a repeating unit (A-4) represented by Formula (4), a repeating unit (A-5) represented by Formula (5), a repeating unit (A-6) represented by Formula (6), an anionic repeating unit (A-7), and a repeating unit (A-8) represented by Formula (8):

wherein, R 1 represents an alkylene group having 2 to 4 carbon atoms; R 2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 3 represents a hydrogen atom or a methyl group; R 4 represents —O—, *—(C═O)—O—, *—(C═O)—NR 5 —, *—NR 5 —(C═O)— where R 5 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and * represents a position at which the group is bound to a carbon atom bound with R 3 in the Formula (1), or a phenylene group; and n represents a value of 2 to 100;

wherein, R 6 represents a hydrogen atom or a methyl group; R 7 represents an alkylene group having 2 to 4 carbon atoms; R 8 represents an alkylene group having 1 to 10 carbon atoms; R 9 , R 10 and R 11 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 8 carbon atoms; and q represents a value of 1 to 10;

wherein, R 12 represents a hydrogen atom or a methyl group; and R 13 and R 14 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or hydroxyalkyl group;

wherein, R 15 represents a hydrogen atom or a methyl group; and R 16 and R 17 each independently represent an alkylene group having 1 to 3 carbon atoms;

wherein, R 18 represents an alkylene group having 1 to 5 carbon atoms;

wherein, Y represents —(C═O)O − , —(O═S═O)O − , —O(O═S═O)O − , —(S═O)O − , —O(S═O)O − , —OP(═O)(OR 24 )O − , —OP(═O)(R 24 )O − , —P(═O)(OR 24 )O − , or -P(═O)(R 24 )O − where R 24 represents an alkyl group having 1 to 3 carbon atoms; R 19 represents a hydrogen atom or a methyl group; R 2 ° represents a divalent organic group having 1 to 10 carbon atoms; R 21 and R 22 each independently represent a hydrocarbon group having 1 to 10 carbon atoms; and R 23 represents a divalent organic group having 1 to 10 carbon atoms; and

wherein, R 25 represents a hydrogen atom or a methyl group; R 26 represents —O—, *—(C═O)—O—, *—(C═O)—NR 31 —, *—NR 31 —(C═O)— where R 31 represents a hydrogen atom or an organic group having 1 to 10 carbon atoms, and * represents a position at which the group is bound to a carbon atom bound with R 25 in the Formula (8), or a phenylene group; R 27 represents a divalent organic group having 1 to 10 carbon atoms; and R 28 , R 29 and R 30 each independently represent a hydrocarbon group having 1 to 10 carbon atoms, wherein the repeating unit (A-8) has a counter ion.

10. The method according to claim 9 , wherein in Formula (1), R 4 represents *—(C═O)—O— and * represents a position at which the group is bound to a carbon atom bound with R 3 in the Formula (1), or a phenylene group.