IP Library Granted Patent US 10,995,310
Granted Patent B2
US 10,995,310 · App. 15/755,087 · Granted May 4, 2021

Biomanufacturing apparatus

Inventors: Praveen Paul (Bangalore, IN); Manoj Ramakrishna (Bangalore, IN); Anoop Bhargav (Bangalore, IN); Haresh Digambar Patil (Bangalore, IN); Sebastian John (Bangalore, IN); Manish Uddhaorao Choudhary (Bangalore, IN); Pradeep Kumar (Bangalore, IN); Nivedita Phadke (Bangalore, IN)
Assignee: Global Life Sciences Solutions USA LLC
C12M27/16C12M21/04C12M23/14C12M23/26C12M29/10C12M41/12C12M41/14
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Quick Facts
Patent No.
US 10,995,310
App. No.
15/755,087
Granted
May 4, 2021
Kind
B2
Abstract

Disclosed is biomanufacturing apparatus 1 comprising a housing 20 including top 22 and bottom 24 faces which allow stacking of plural housings, an access door 25 at a front side of the housing, a substantially enclosed bioreactor chamber 30 inside the housing accessible via the door, and a further substantially enclosed region 36 inside the housing containing electrical parts and/or electronic control components, the chamber 30 including: a tray 40 for supporting a bioreactor, a tray support 45 including a mechanism 44,47 for rocking the tray in use; the tray support further including a load cell ( 41 ) to determine changes in the mass load on the tray.

Claims (24)

1. A biomanufacturing apparatus comprising a housing including top and bottom faces which allow stacking of plural housings,

an access door at a front side of the housing,

a substantially enclosed bioreactor chamber inside the housing accessible via the access door, and

a further substantially enclosed region inside the housing containing at least one of electrical parts and electronic control components,

wherein the chamber includes:

a tray for supporting a bioreactor, and

a tray support including a mechanism for rocking the tray in use, the tray support further including a load cell to determine changes in a mass load on the tray, wherein the mechanism for rocking the tray is configured to move a plate holder back and forth about a pivot axis below the tray,

wherein the tray support further includes a sliding portion for automatically sliding the tray at least partially out of the chamber via an open door, the sliding portion being arranged such that when inclined by the mechanism for rocking, a portion of the mass load on the tray is reacted by the housing and therefore is not transmitted through the load cell, wherein the sliding portion is mounted between the tray and the mechanism for rocking the tray that is located above the load cell.

2. The apparatus of claim 1 , wherein: the load cell is mounted to the floor of the chamber; the mechanism for rocking is mounted on the load cell; and the tray is mounted on the mechanism for rocking.

3. The apparatus of claim 1 , wherein: the chamber has a main chamber region for housing the tray and the tray support, and an antechamber region shallower in depth relative to the access door than the main chamber region, the antechamber region including a panel to which is mounted at least one fluid pump device such that fluid handling portion(s) of the at least one fluid pump device project beyond the panel into the antechamber region.

4. The apparatus of claim 3 , wherein at least one connection is mounted to the panel, said at least one connection being adapted for removably connecting one or more of: a gas conduit; a pH sensor connection path; and a dissolved oxygen sensor connection path.

5. The apparatus of claim 1 , wherein the tray is at least one of slidable relative to and removable from, the tray support.

6. The apparatus of claim 5 , wherein the access door includes a further tray support for supporting the tray on the access door when the access door is open, the further tray support being collapsible to allow the access door to close.

7. The apparatus of claim 1 , wherein the load cell is a mechanical strain sensor, operable to determine the changes in the mass load supported on the tray.

8. The apparatus of claim 1 , further including a bioreactor heater mounted at the tray for conductive heating of the bioreactor, and a chamber air heater for convective heating the gaseous atmosphere in the chamber, each heater being controlled by a temperature control.

9. The apparatus of claim 1 , wherein said top and bottom faces are generally flat and include height adjustable feet.

10. The apparatus of claim 1 , further including a support external to the housing to one side of the access door for supporting at least one of consumable materials and fluid products.

11. The apparatus of claim 4 , further including the bioreactor in the form of flexible bag supported on the tray, said flexible bag including fluid conduits passing via pump heads connected or connectable to connections.

12. The apparatus of claim 1 , wherein the bioreactor has a capacity of between approximately 50 millilitres and 2500 millilitres.

13. The apparatus of claim 1 , wherein the tray or the tray support includes a reader for recognizing the identity of the bioreactor mounted on the tray.

14. The apparatus of claim 1 , wherein the chamber, with the access door closed, reduces or substantially excludes visible light.

15. The apparatus of claim 1 , wherein the access door includes a status display viewable from at least one of the outside of the access door and a window for viewing the chamber.

16. A biomanufacturing system, comprising, a plurality of stacked biomanufacturing apparatus of claim 1 , in data communication with a central computer including software operable to at least one of monitor the status of and control one or more of the apparatus.

17. The apparatus of claim 10 , wherein the at least one of consumable materials and fluid products comprises at least one of bagged waste and biomolecules.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 1, 2020
From: GENERAL ELECTRIC COMPANY
To: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
Reel/Frame 053966/0133 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 26, 2018
From: PAUL, PRAVEEN; RAMAKRISHNA, MANOJ; BHARGAV, ANOOP; PATIL, HARESH DIGAMBAR; JOHN, SEBASTIAN; CHOUDHARY, MANISH UDDHAORAO; KUMAR, PRADEEP; PHADKE, NIVEDITA
To: GENERAL ELECTRIC COMPANY
Reel/Frame 045043/0775 →
Priority Claims (3)
IN 2632/DEL/2015 · Aug 25, 2015 · national
GB 1518426 · Oct 19, 2015 · national
IN 201611027824 · Aug 16, 2016 · national
Continuity (1)
Related Publication 20180251715A1 · Sep 6, 2018