Method for generating an electro spun fiber medical implant
A method for generating a electro spun fiber medical implant including determining dimensions of a portion of anatomy of a patient corresponding to the electro spun fiber medical implant via medical imaging, generating a model of the portion of the anatomy based on the dimensions, the model including one or more solid areas and one or more void areas encompassed within the one or more solid areas, inverting the model to generate a mandrel model, the mandrel model generated based on the one or more void areas, generating the mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein, and applying an electro-spinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein the mandrel is removable from within the electro spun fiber medical implant after a disassembly process.
1. A method for generating an electro spun fiber medical implant, comprising:
generating a digital implant model based on dimensions of the electro spun fiber medical implant corresponding to a portion of anatomy of a patient, the dimensions being determined via medical imaging;
applying one or more fluid flow simulations to the digital implant model;
updating the digital implant model based on the applying the one or more fluid flow simulations to the digital implant model;
generating a mandrel model by inverting the digital implant model;
generating a mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein; and
applying an electrospinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein
the mandrel is removable from within the electro spun fiber medical implant after a disassembly process, and
the digital implant model includes one or more solid areas and one or more void areas encompassed within the one or more solid areas.
2. The method according to claim 1 , wherein the electro spun fiber medical implant is a patient-specific electro spun fiber tissue engineered vascular graft (TEVG) based on the portion of anatomy of the patient.
3. The method according to claim 1 , wherein the generating the mandrel further comprises printing the mandrel using a 3D printer.
4. The method according to claim 1 , wherein the mandrel is composed of several interlocking pieces that disconnect during the disassembly process.
5. The method according to claim 1 , wherein the mandrel includes more than one electrically conductive material therein.
6. The method according to claim 1 , wherein the mandrel including at least one electrically conductive material on the surface thereof.
7. The method according to claim 1 , wherein the electrically conductive material is disposed at varying locations within or on the mandrel resulting in a conductivity gradient across the mandrel.
8. The method according to claim 7 , wherein the applying the electrospinning process to the mandrel further comprises applying the electrospinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel and which has electro spun fiber deposited in a concentrated fashion in different areas of the electro spun fiber medical implant.
9. The method according to claim 1 , wherein the applying the one or more fluid flow simulations to the digital implant model further comprises:
evaluating a blood pressure differential along a length of the electro spun fiber medical implant.