Formulation for the treatment of acne
Peroxide of the formula wherein R 1 is selected from linear and branched alkyl groups with 1-4 carbon atoms, and R 2 , R 3 , and R 4 are selected from hydrogen and linear and branched alkyl groups with 1-4 carbon atoms, for use as a medicament, in particular for the treatment of acne.
1. A method of treatment of acne comprising topical application to skin of an effective amount of peroxide of the formula
wherein R 1 is selected from linear and branched alkyl groups with 1-4 carbon atoms, and R 2 , R 3 , and R 4 are selected from hydrogen and linear and branched alkyl groups with 1-4 carbon atoms.
2. The method of claim 1 wherein R 1 and R 2 are selected from methyl, tert-butyl, and n-butyl groups.
3. The method of claim 1 wherein R 3 and R 4 are both hydrogen.
4. The method of claim 3 wherein R 1 and R 2 are positioned at the para position.
5. The method of claim 1 wherein the peroxide is di(4-methylbenzoyl)peroxide.
6. A method of inhibiting the proliferation of Staphylococcus aureus, Staphylococcus epidermidis , and/or Propionibacerium acnes to a subject in need thereof; comprising the topical application of an effective amount of a peroxide with the formula
wherein R 1 is selected from linear and branched alkyl groups with 1-4 carbon atoms, and R 2 , R 3 , and R 4 are selected from hydrogen and linear and branched alkyl groups with 1-4 carbon atoms.
7. The method of claim 6 wherein the peroxide is di(4-methylbenzoyl)peroxide.