T cell receptors (TCR) and uses thereof for the diagnosis and treatment of diabetes

1. A zinc transporter 8 (ZnT8)-specific T cell receptor (TCR) comprising an α chain and a β chain, wherein the CDR3 sequences of the β chain and the α chain comprise amino acid sequences as set forth in:

SEQ ID NO:1 and SEQ ID NO:2 respectively, or

SEQ ID NO:3 and SEQ ID NO:4 respectively, or

SEQ ID NO:5 and SEQ ID NO:6 respectively, or

SEQ ID NO:7 and SEQ ID NO:8 respectively, or

SEQ ID NO:9 and SEQ ID NO:10 or SEQ ID NO:11 respectively, or

SEQ ID NO:12 and SEQ ID NO:13 respectively, or

SEQ ID NO:14 and SEQ ID NO:15 respectively, or

SEQ ID NO:16 and SEQ ID NO:17 or SEQ ID NO:18 respectively, or

SEQ ID NO:19 and SEQ ID NO:20 respectively, or

SEQ ID NO:21 and SEQ ID NO:22 respectively, or

SEQ ID NO:23 and SEQ ID NO:24 respectively.