Formation of bone
Compositions and methods for inducing or promoting repair of a bone fracture.
1. A method of inducing formation of bone in an individual consisting essentially of the steps of
providing an individual having a bone fracture or void requiring bone formation, and
providing a therapeutically effective amount of uncrosslinked tropoelastin to the individual to induce the formation of bone in the individual,
thereby inducing bone formation in the individual, wherein the tropoelastin is administered by injection.
2. The method of claim 1 , wherein the defect is a fracture and the individual is provided with the tropoelastin to promote the repair of the fracture.
3. The method of claim 2 , wherein the tropoelastin is administered directly to bone at the site of the fracture.
4. The method of claim 1 wherein the tropoelastin is administered directly to the bone callus.
5. The method of claim 4 wherein the tropoelastin is administered in the form of a gel, putty or paste.
6. The method of claim 5 wherein the tropoelastin is administered to a periosteal surface.
7. The method of claim 1 , wherein the defect is a void.
8. The method of claim 7 wherein the tropoelastin is administered directly to the bone at the site of the bone void.
9. The method of claim 8 wherein the tropoelastin is administered directly to the bone callus.
10. The method of claim 9 wherein the tropoelastin is administered by injection.
11. The method of claim 10 wherein the tropoelastin is administered in the form of a gel, putty or paste.
12. The method of claim 11 wherein the tropoelastin is administered to a periosteal surface.
13. The method of claim 1 , wherein the tropoelastin is a SHELδ26A, as shown in SEQ ID NO: 1.