Agent capable of depleting CD8 T cells for the treatment of myocardial infarction or acute myocardial infarction

Inventor: Hafid Ait-Oufella (Paris, FR)

Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale); Université Paris Descartes; Assistance Publique-Hôpitaux de Paris (APHP)

C07K16/2815 A61K47/6849 A61K2039/505

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Quick Facts

Patent No.: US 10,556,953
App. No.: 15/759,850
Granted: Feb 11, 2020
Kind: B2

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Abstract

The present invention relates to a method for treating MI or AMI in a subject in need thereof comprising a step of administering to said subject a therapeutically effective amount of an agent capable of depleting CD8 T cells. More particularly, this present invention relates to a method for treating acute myocardial infarction by reducing the size of necrosis and limiting 10 the post ischemic left ventricular remodeling.

Claims (3)

1. A method for treating myocardial infarction (MI) or acute myocardial infarction (AMI) in a subject in need thereof comprising the step of administering to said subject within 14 days of the infarction a therapeutically effective amount of an anti-CD8 antibody capable of depleting CD8 T cells.

2. The method of claim 1 , wherein the anti-CD8 antibody is a monoclonal antibody.

3. The method of claim 1 , wherein the anti-CD8 antibody is a monoclonal antibody conjugated to a cytotoxic agent.

Assignments (3)

CHANGE OF NAME Recorded May 12, 2022

From: UNIVERSITE DE PARIS

To: UNIVERSITÉ PARIS CITÉ

Reel/Frame 059988/0388 →

MERGER Recorded May 12, 2022

From: UNIVERSITE PARIS DESCARTES

To: UNIVERSITE DE PARIS

Reel/Frame 060044/0856 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2018